The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.
about
Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal stateCrystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and CarvedilolStabilization of G protein-coupled receptors by point mutations.The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands.GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation.Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines.
P2860
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P2860
The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.
description
2011 nî lūn-bûn
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
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2011年论文
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name
The pharmacological effects of ...... of the turkey β-adrenoceptor.
@en
The pharmacological effects of the thermostabilising
@nl
type
label
The pharmacological effects of ...... of the turkey β-adrenoceptor.
@en
The pharmacological effects of the thermostabilising
@nl
prefLabel
The pharmacological effects of ...... of the turkey β-adrenoceptor.
@en
The pharmacological effects of the thermostabilising
@nl
P2860
P1476
The pharmacological effects of ...... of the turkey β-adrenoceptor.
@en
P2093
Richard G W Proudman
P2860
P2888
P356
10.1007/S00210-011-0648-4
P577
2011-05-06T00:00:00Z