about
Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune responseFragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.Direct pathway T-cell alloactivation is more rapid than indirect pathway alloactivation.Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.Firmly tilting the balance of clinical transplant immunity toward tolerance
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thomas Thornley
@ast
Thomas Thornley
@en
Thomas Thornley
@es
Thomas Thornley
@nl
Thomas Thornley
@sl
type
label
Thomas Thornley
@ast
Thomas Thornley
@en
Thomas Thornley
@es
Thomas Thornley
@nl
Thomas Thornley
@sl
prefLabel
Thomas Thornley
@ast
Thomas Thornley
@en
Thomas Thornley
@es
Thomas Thornley
@nl
Thomas Thornley
@sl
P106
P1153
11839961900
P21
P31
P496
0000-0001-5296-6825