about
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blockerBI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose HomeostasisExosomes: from biogenesis and secretion to biological functionPurification and molecular characterization of recombinant rat betacellulinADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx.Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors.Syk: a novel target for treatment of inflammation in lung disease.A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques.Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion.L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding.A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation.An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor.Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Michael Sanderson
@ast
Michael Sanderson
@en
Michael Sanderson
@es
Michael Sanderson
@nl
Michael Sanderson
@sl
type
label
Michael Sanderson
@ast
Michael Sanderson
@en
Michael Sanderson
@es
Michael Sanderson
@nl
Michael Sanderson
@sl
prefLabel
Michael Sanderson
@ast
Michael Sanderson
@en
Michael Sanderson
@es
Michael Sanderson
@nl
Michael Sanderson
@sl
P1053
I-1674-2017
P106
P21
P31
P3829
P496
0000-0001-5362-486X