Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.
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Expression and alternative splicing of the cytochrome P-450 CYP2A7P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissuesMolecular genetics of the human cytochrome P450 monooxygenase superfamilyAMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineExamination of 209 drugs for inhibition of cytochrome P450 2C8Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathwaysInactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison.The role of CYP2B6 in human xenobiotic metabolism.Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy.AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet.Transient induction of ANG II-dependent malignant hypertension causes sustained elevation of blood pressure and augmentation of the pressor response to ANG II in CYP1A1-REN2 transgenic ratsIn vivo regulation of human glutathione transferase GSTP by chemopreventive agents.Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systemsHuman drug metabolism and the cytochromes P450: application and relevance of in vitro models.CYP2B6: new insights into a historically overlooked cytochrome P450 isozymeCyclophosphamide and cancer: golden anniversary.An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activityChronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension.Regulation of cytochrome P450 gene expression in human colon and breast tumour xenograftsMicrosomal prediction of in vivo clearance of CYP2C9 substrates in humans.Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Possible carcinogenic potential of dimethyl dimethoxy biphenyl dicarboxylate in experimental animals.Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues.A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor.A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide.In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability.In vitro drug metabolism testing using blood-monocyte derivatives.Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice.Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.The application of in vitro models of drug metabolism and toxicity in drug discovery and drug development.Pharmacokinetics and tolerability of GW420867X, a nonnucleoside reverse transcriptase inhibitor, following single escalating doses in healthy male volunteers.
P2860
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P2860
Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@en
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@nl
type
label
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@en
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@nl
prefLabel
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@en
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@nl
P2093
P2860
P356
P1433
P1476
Relative expression of cytochr ...... lism of drugs and xenobiotics.
@en
P2093
Forrester LM
Glancey MJ
Henderson CJ
Kitteringham NR
McLaren AW
P2860
P304
P356
10.1042/BJ2810359
P407
P478
281 ( Pt 2)
P577
1992-01-01T00:00:00Z