Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases
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Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosomeA novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stabilityp14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activityNovel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functionsp53-independent functions of the p19(ARF) tumor suppressorRole of the F-box protein Skp2 in lymphomagenesisExpression of coxsackie and adenovirus receptor distinguishes transitional cancer states in therapy-induced cellular senescenceOncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy.Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging.Role of p14(ARF) in replicative and induced senescence of human fibroblasts.C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence.ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.Exploiting tumor cell senescence in anticancer therapyHeterogeneous activation of p19Arf in pulmonary artery smooth muscle cells.The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway.P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.Therapeutic targets in the ARF tumor suppressor pathway.IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells.A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgroundsINK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescenceNoncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling.Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions.Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress.SHARPIN negatively associates with TRAF2-mediated NFκB activation.
P2860
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P2860
Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@en
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@nl
type
label
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@en
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@nl
prefLabel
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@en
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@nl
P2093
P356
P1476
Oncogenic Ras induces p19ARF a ...... ing cyclin D-dependent kinases
@en
P2093
P304
27473-27480
P356
10.1074/JBC.M003417200
P407
P577
2000-09-01T00:00:00Z