Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. - Wikidata - wikimedia - TriplyDB

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

http://www.wikidata.org/entity/Q42806046

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Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses Germline KRAS mutations cause Noonan syndrome Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9 Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro Network analysis of oncogenic Ras activation in cancer.Characterization of rare transforming KRAS mutations in sporadic colorectal cancer.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.KRAS insertion mutations are oncogenic and exhibit distinct functional properties.A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth Mechanistic modeling to investigate signaling by oncogenic Ras mutants.KRAS status analysis and anti-EGFR therapies: is comprehensiveness a biologist's fancy or a clinical necessity?Biochemical and functional characterization of germ line KRAS mutations.Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer.Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b.New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.

P2860

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P2860

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

http://www.wikidata.org/entity/Q42806046

description

1996 nî lūn-bûn

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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1996年论文

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1996年论文

@zh-cn

name

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

@en

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

@nl

type

label

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

@en

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

@nl

prefLabel

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

@en

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

@nl

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Journal of Biological Chemistry

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Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

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Adler F

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Bollag G

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Conner E Jr

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McCormick F

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elMasry N

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P2860

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

The GTPase superfamily: conserved structure and molecular mechanism

Activation of the MAP kinase pathway by the protein kinase raf

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Proteins regulating Ras and its relatives

The GTPase superfamily: a conserved switch for diverse cell functions

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

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