Two catalytic domains are required for protein deacetylation.
about
The role of HDAC6 in cancerThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationCYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulinHDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylationHistone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosisThe deacetylase HDAC6 is a novel critical component of stress granules involved in the stress responseHistone deacetylase 6 plays a role as a distinct regulator of diverse cellular processesHDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neuronsStructural insights into HDAC6 tubulin deacetylation and its selective inhibitionMice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.Aggresome formation and neurodegenerative diseases: therapeutic implicationsHDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesisHDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesIIp45 inhibits cell migration through inhibition of HDAC6Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes.The clinical development of histone deacetylase inhibitors as targeted anticancer drugs.New perspectives of valproic acid in clinical practice.Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.Target engagement and drug residence time can be observed in living cells with BRET.SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity.aPKC phosphorylation of HDAC6 results in increased deacetylation activityHistone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer.Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stressModulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylationRegulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiationHDAC6 and ovarian cancer.Alcohol-induced protein hyperacetylation: mechanisms and consequencesHdac6 regulates Tip60-p400 function in stem cells.Computational studies on the histone deacetylases and the design of selective histone deacetylase inhibitors.Trans-regulation of histone deacetylase activities through acetylationEpigenetic Modulation of Stem Cells in Neurodevelopment: The Role of Methylation and Acetylation.Novel approaches to the treatment of sickle cell disease: the potential of histone deacetylase inhibitors.Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.HDAC6 regulates sensitivity to cell death in response to stress and post-stress recoveryHistone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesisHistone deacetylase 6 structure and molecular basis of catalysis and inhibition.HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.Determination of protein lysine deacetylation.
P2860
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P2860
Two catalytic domains are required for protein deacetylation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Two catalytic domains are required for protein deacetylation.
@en
Two catalytic domains are required for protein deacetylation.
@nl
type
label
Two catalytic domains are required for protein deacetylation.
@en
Two catalytic domains are required for protein deacetylation.
@nl
prefLabel
Two catalytic domains are required for protein deacetylation.
@en
Two catalytic domains are required for protein deacetylation.
@nl
P2093
P2860
P356
P1476
Two catalytic domains are required for protein deacetylation
@en
P2093
Benoit Gilquin
Patrick Matthias
P2860
P304
P356
10.1074/JBC.C500241200
P407
P577
2005-11-06T00:00:00Z