Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
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Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking grooveSubstrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifsRequirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survivalSustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells.Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner.A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatasesCystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways.ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events.Characterization of ERK docking domain inhibitors that induce apoptosis by targeting Rsk-1 and caspase-9.ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer.Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactionsGnRH signaling, the gonadotrope and endocrine control of fertility.Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer.Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localizationQuantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity.Inhibition of ERK-MAP kinase signaling by RSK during Drosophila developmentOCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancerBoth ERK1 and ERK2 are required for enterovirus 71 (EV71) efficient replication.Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structureDown-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.MAP kinase pathways: the first twenty years.Examining docking interactions on ERK2 with modular peptide substrates.Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRafc-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancerExtracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.MAP kinases and the control of nuclear events.Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelopeThe roles of MAPKs in disease.Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study.In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.The histone demethylase PHF8 is a molecular safeguard of the IFNγ response.Autophagy proteins regulate ERK phosphorylation.Protection from interferon-β-induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation.Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions.Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt SignalingDEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors
P2860
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P2860
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@en
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@nl
type
label
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@en
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@nl
prefLabel
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@en
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@nl
P2093
P1433
P1476
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo.
@en
P2093
Christopher A Dimitri
Jeffrey P MacKeigan
John Blenis
Leon O Murphy
William Dowdle
P304
P356
10.1016/J.CUB.2005.06.037
P407
P577
2005-07-01T00:00:00Z