Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization.
about
K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and functionThe Key Role of Calmodulin in KRAS-Driven AdenocarcinomasSeparate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibitionRas, an actor on many stages: posttranslational modifications, localization, and site-specified events.Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulinCharacterization and functional analysis of the calmodulin-binding domain of Rac1 GTPaseMechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.A New View of Ras Isoforms in Cancers.Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration.A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes.The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulinPrinciples of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.Calmodulin and PI3K Signaling in KRAS Cancers.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.Regulation of K-Ras4B Membrane Binding by Calmodulin.CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators.Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to-mesenchymal transition of non-small cell lung cancer cells by blocking KRas to calmodulin binding.Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor-dependent manner.Requirement for PLCγ2 in IL-3 and GM-CSF-stimulated MEK/ERK phosphorylation in murine and human hematopoietic stem/progenitor cells.
P2860
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P2860
Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification of essential in ...... ts role in K-Ras localization.
@en
Identification of essential in ...... ts role in K-Ras localization.
@nl
type
label
Identification of essential in ...... ts role in K-Ras localization.
@en
Identification of essential in ...... ts role in K-Ras localization.
@nl
prefLabel
Identification of essential in ...... ts role in K-Ras localization.
@en
Identification of essential in ...... ts role in K-Ras localization.
@nl
P2093
P2860
P356
P1476
Identification of essential in ...... ts role in K-Ras localization.
@en
P2093
Blanca Alvarez-Moya
Cristina Lopez-Alcalá
Maria Calvo
Oriol Bachs
Priam Villalonga
P2860
P304
10621-10631
P356
10.1074/JBC.M706238200
P407
P50
P577
2008-01-08T00:00:00Z