about
Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VIS1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue DestructionAssembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspSA Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) SyndromeA molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritisStructural basis for substrate specificity of Helicobacter pylori M17 aminopeptidasePrediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display.Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions.Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.The effects of exosite occupancy on the substrate specificity of thrombin.Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabieiScabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathwayDiscovery of amino acid motifs for thrombin cleavage and validation using a model substrate.The role of the lys628 (192) residue of the complement protease, c1s, in interacting with Peptide and protein substrates.Novel scabies mite serpins inhibit the three pathways of the human complement system.Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein.Snake venom probes of platelet adhesion receptors and their ligands.A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasitesThe initiating proteases of the complement system: controlling the cleavage.The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis.The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition.Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates.Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism.Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites.Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism.Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.Serpins and the Complement SystemEffect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombinFractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose
P50
Q24299819-80B4C678-5CA1-43DF-A124-AF099FB8B83FQ27674974-C726B1ED-46D7-46CF-A39C-BB6CACE0CE3CQ27675923-4F973B9F-63B0-4665-A346-FC088D7D7242Q27677421-AEA680DF-01F0-4508-928B-794458AD84F5Q27678744-6DE1BB27-750F-4ABC-B99B-281652AF008DQ27680522-AC0398F0-DFAF-4C7E-9DD0-EC2BC59F0AC4Q27702892-6C240AF0-4551-45C6-B348-9B3656DAE461Q30844421-5AA56A20-402A-4393-9DE5-F510F87823C5Q33208275-ABE14C12-2F85-4283-906A-969063494329Q33215766-ABD03D62-B77A-4E44-A290-2BED373315BCQ33294670-6001F5BA-185C-4E92-81C2-9681B53287B7Q33488133-1F47B2B3-0806-4420-BEF7-B38B8F9649D2Q33509255-0EE9DE33-2440-467E-ADE5-ECAFE1D3BA1EQ33650125-727EAECA-55E6-41A8-A81C-BC434B137608Q34066090-7FE4E699-F3EF-4786-AEB6-ABE4DBF77CBAQ34198704-538510F6-3DE2-4E7E-814C-64D958BA9671Q34336401-7954561C-0464-4080-A676-601621C40571Q34669864-7EAA6DCD-6FFB-4E6F-8553-D80B2E56244FQ35116875-C5EB44DE-9767-4B2B-8C54-9DCF2AF61EE6Q36143048-ED6BFEDA-4699-4613-943B-9827C01E88AAQ36444217-C56039CF-3A44-41CC-BEAF-A06241F8964EQ36938835-5E540807-5DDE-4A22-8C81-4C252E0262DAQ37470595-845265E5-751E-45BF-ABF1-6D3895538067Q37887585-95BEB983-4BCB-4C27-981F-7834DC90CA86Q37888146-28668B37-6DD6-48E6-AB2F-3E0209A00626Q38127985-E74FDA22-0381-4488-AF11-D733E49070F7Q39575679-18C7DB27-206F-4DBB-9A2A-2A17BEFC3BBCQ39900355-3E830835-E3AB-4120-9D96-8A7F2FA488B9Q40220841-4C77E8E2-225C-41EF-BF28-0717AB668E75Q40505389-429F6BA1-48BE-478B-B18D-54FD5D12722BQ40780310-AAE5434B-1F0C-4740-A80F-FBB67EBC1B02Q41663740-8407BC8B-692E-49AF-B0BB-C5CEE2284CA5Q44626274-46053045-CD67-4BC4-8D81-7F91B21C9DDDQ46003832-3A2D7936-1A10-4A37-8009-0FFF6D415188Q47614108-3430DAC5-7F0B-44DA-A8B8-63A2C27A3BC9Q50324222-D61AB557-53E7-4F66-938B-10A9A78D1DDBQ53512260-0F87C58B-4DED-4A72-BD36-E56404FB10A6Q57079392-377F4CCE-9121-485B-8B6F-8ACA785D0515Q58023110-77DD1944-D389-4EB6-B905-796ECE7E182DQ59281481-8599F08D-A0E9-47D2-85C6-C6A7F80D1912
P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Lakshmi Wijeyewickrema
@ast
Lakshmi Wijeyewickrema
@en
Lakshmi Wijeyewickrema
@es
Lakshmi Wijeyewickrema
@nl
Lakshmi Wijeyewickrema
@sl
type
label
Lakshmi Wijeyewickrema
@ast
Lakshmi Wijeyewickrema
@en
Lakshmi Wijeyewickrema
@es
Lakshmi Wijeyewickrema
@nl
Lakshmi Wijeyewickrema
@sl
prefLabel
Lakshmi Wijeyewickrema
@ast
Lakshmi Wijeyewickrema
@en
Lakshmi Wijeyewickrema
@es
Lakshmi Wijeyewickrema
@nl
Lakshmi Wijeyewickrema
@sl
P1053
A-9676-2015
P106
P21
P31
P3829
P496
0000-0001-6084-4887
P569
2000-01-01T00:00:00Z