A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.
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Identification of AML1-ETO modulators by chemical genomicsIdentification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity.Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.Effect of noncompetitive proteasome inhibition on bortezomib resistance.The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosisClioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathwayA virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivoCatalase activity and arsenic sensitivity in acute leukemia.CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil.A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myelomaThe ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discoveryDexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myeloma.A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathwayThe antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.An anti-leishmanial thiadiazine agent induces multiple myeloma cell apoptosis by suppressing the nuclear factor kappaB signalling pathway.An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathwayRole of c-Maf in Chondrocyte Differentiation: A Review.MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma.Natural pesticide dihydrorotenone arrests human plasma cancer cells at the G0/G1 phase of the cell cycle.Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis.Transforming growth factor-β-activated kinase 1 resistance limits glucocorticoid responsiveness to Toll-like receptor 4-mediated inflammation.
P2860
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P2860
A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A chemical biology screen iden ...... gh up-regulation of ubiquitin.
@en
A chemical biology screen iden ...... gh up-regulation of ubiquitin.
@nl
type
label
A chemical biology screen iden ...... gh up-regulation of ubiquitin.
@en
A chemical biology screen iden ...... gh up-regulation of ubiquitin.
@nl
prefLabel
A chemical biology screen iden ...... gh up-regulation of ubiquitin.
@en
A chemical biology screen iden ...... gh up-regulation of ubiquitin.
@nl
P2093
P50
P1433
P1476
A chemical biology screen iden ...... ugh up-regulation of ubiquitin
@en
P2093
A Keith Stewart
Changxin Shi
Dwayne L Barber
Jeffery L Wrana
Lisa C Gillis
Rose Hurren
Seth J Corey
Shengben Liang
Xinliang Mao
P304
P356
10.1182/BLOOD-2007-05-088666
P407
P577
2007-09-17T00:00:00Z