F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

@en

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

@nl

type

Item

label

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

@en

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

@nl

prefLabel

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

@en

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

@nl

P1476

F604S exchange in FIP1L1-PDGFR ...... f kinase inhibitor resistance.

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P2093

A L Illert

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A Reiter

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C Yu

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J Duyster

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K Zirlik

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N Von Bubnoff

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S P Gorantla

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P2860

Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases

Role for the adaptor protein Grb10 in the activation of Akt

Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

Crystal structure of the tyrosine phosphatase SHP-2

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.

FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia

The SH2-containing adapter protein GRB10 interacts with BCR-ABL

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leu.2015.70

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1763-1770

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10.1038/LEU.2015.70

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1038638626

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