Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias.
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Fibroblast growth factor signaling in skeletal development and diseaseFibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesisSixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasiasBMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formationAnalysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilageNew insight on FGFR3-related chondrodysplasias molecular physiopathology revealed by human chondrocyte gene expression profilingIdentification of SOX9 interaction sites in the genome of chondrocytesHeparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasiaMutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytesSTAT5 acts as a repressor to regulate early embryonic erythropoiesis.Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.FGF signaling in the developing endochondral skeleton.Whole-genome sequencing reveals a potential causal mutation for dwarfism in the Miniature Shetland pony.Thanatophoric Dysplasia: A Case ReportTyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytesFGFR3-related dwarfism and cell signaling.Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible.Transcriptional control of chondrocyte specification and differentiation.Achondroplasia: Development, pathogenesis, and therapy.Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification.Mutations in different components of FGF signaling in LADD syndrome.Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner.Human immortalized chondrocytes carrying heterozygous FGFR3 mutations: an in vitro model to study chondrodysplasias.Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins.Phosphate regulates embryonic endochondral bone developmentInduction of mesenchymal stem cell chondrogenesis through sequential administration of growth factors within specific temporal windows.Direct anti-cancer effect of oncostatin M on chondrosarcoma.FGFR3 mutation causes abnormal membranous ossification in achondroplasiaThe Muenke syndrome mutation (FgfR3P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses
P2860
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P2860
Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
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2004年论文
@zh-cn
name
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@en
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@nl
type
label
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@en
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@nl
prefLabel
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@en
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@nl
P1433
P1476
Overexpression of FGFR3, Stat1 ...... FR3-related chondrodysplasias.
@en
P2093
Benoist-Lasselin C
Bonaventure J
P356
10.1016/J.BONE.2003.09.002
P577
2004-01-01T00:00:00Z