Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions.
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Studying GPCR/cAMP pharmacology from the perspective of cellular structureReversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts.Cyclic AMP enhances TGFβ responses of breast cancer cells by upregulating TGFβ receptor I expression.cAMP level modulates scleral collagen remodeling, a critical step in the development of myopiaCaffeine and rolipram affect Smad signalling and TGF-β1 stimulated CTGF and transgelin expression in lung epithelial cells.Low-power laser irradiation inhibits arecoline-induced fibrosis: an in vitro studyInterplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation.The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor β1 in Hepatic Stellate Cells.Glycogen synthase kinase-3 (GSK-3) regulates TGF-β₁-induced differentiation of pulmonary fibroblasts.Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling.Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β.Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model.Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology.Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells.Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis.The parathyroid hormone regulates skin tumour susceptibility in mice.Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop.Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells.Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis.Calcitonin gene-related peptide regulates mitogen-activated protein kinase pathway to decrease transforming growth factor β1-induced hepatic plasminogen activator inhibitor-1 mRNA expression in HepG2 cells.Antifibrotic effects of pirfenidone in rat proximal tubular epithelial cells.Prostaglandin E2 Antagonizes TGF-β Actions During the Differentiation of Monocytes Into Dendritic Cells.
P2860
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P2860
Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Increased cAMP levels modulate ...... fibroblast effector functions.
@en
Increased cAMP levels modulate ...... fibroblast effector functions.
@nl
type
label
Increased cAMP levels modulate ...... fibroblast effector functions.
@en
Increased cAMP levels modulate ...... fibroblast effector functions.
@nl
prefLabel
Increased cAMP levels modulate ...... fibroblast effector functions.
@en
Increased cAMP levels modulate ...... fibroblast effector functions.
@nl
P2093
P2860
P356
P1476
Increased cAMP levels modulate ...... fibroblast effector functions
@en
P2093
Agatha Kokot
Jan C Simon
Markus Böhm
Meinhard Schiller
Sylviane Dennler
Thomas A Luger
Ulf Anderegg
P2860
P304
P356
10.1074/JBC.M109.038620
P407
P577
2009-10-26T00:00:00Z