Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.
about
Cloning and characterization of a mammalian prenyl protein-specific proteasePrenylated prelamin A interacts with Narf, a novel nuclear proteinErf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae.Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubulesRas-induced cellular events (review)Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformationFarnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gammaThe tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosisH-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cellsThe growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathwayThe EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent mannerTargeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cellsRas, an actor on many stages: posttranslational modifications, localization, and site-specified events.Clinical relevance of KRAS in human cancers.Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression.Ras isoform-specific signaling: location, location, location.Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae.Oncogenic Ras in tumour progression and metastasis.Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.Nonconventional trafficking of Ras associated with Ras signal organization.Structural model of a complex between the heterotrimeric G protein, Gsalpha, and tubulinGenetic analyses of the role of RCE1 in RAS membrane association and transformation.Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.Isoform-specific ras functions in development and cancer.The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins.H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.The pseudorabies virus Us2 protein, a virion tegument component, is prenylated in infected cells.Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line.Differential activation of the Rac pathway by Ha-Ras and K-Ras.Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.Functional specificity of ras isoforms: so similar but so different.Disrupting the transforming activity of shrimp ras(Q(61)K) by deleting the CAAX box at the C-terminus.Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery.The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase.Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.Binding and phosphorylation of tubulin by G protein-coupled receptor kinases.
P2860
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P2860
Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Prenylation-dependent associat ...... le in subcellular trafficking.
@en
Prenylation-dependent associat ...... le in subcellular trafficking.
@nl
type
label
Prenylation-dependent associat ...... le in subcellular trafficking.
@en
Prenylation-dependent associat ...... le in subcellular trafficking.
@nl
prefLabel
Prenylation-dependent associat ...... le in subcellular trafficking.
@en
Prenylation-dependent associat ...... le in subcellular trafficking.
@nl
P2093
P2860
P356
P1476
Prenylation-dependent associat ...... le in subcellular trafficking.
@en
P2093
P2860
P304
30362-30370
P356
10.1074/JBC.272.48.30362
P407
P577
1997-11-01T00:00:00Z