Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and/or Fc gamma RII receptors.
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A perspective on the structure and receptor binding properties of immunoglobulin G FcAdvances in Therapeutic Fc Engineering - Modulation of IgG-Associated Effector Functions and Serum Half-lifeA recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments.Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity.Antibody engineering: advances from the use of Escherichia coli expression systems.CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice.Optimized expression of full-length IgG1 antibody in a common E. coli strain.Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling.The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions.Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies.Serum glycan signatures of gastric cancer.The Serum Immunoglobulin G Glycosylation Signature of Gastric CancerHIV-1-specific antibody responses during acute and chronic HIV-1 infectionGenetically-engineered antibodies: tools for the study of diverse properties of the antibody molecule.Recombinant human IgA expressed in insect cells.Revisiting the role of glycosylation in the structure of human IgG Fc.Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1.The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin GFingerprinting of glycans as their 2-aminoacridone derivatives by capillary electrophoresis and laser-induced fluorescence.Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptorsImproving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDCEnrichment strategies in glycomics-based lung cancer biomarker development.Biomarkers of Helicobacter pylori-associated gastric cancer.The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I.Retargeting serum immunoglobulin with bispecific diabodies.Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.Effect of glucose feeding on the glycosylation quality of antibody produced by a human cell line, F2N78, in fed-batch culture.Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering.Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.Current progress in innovative engineered antibodies.Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: the effect of culture mode and the anti-apoptotic gene, bcl-2.Hybrid antibodies.Expression of bioactive anti-CD20 antibody fragments and induction of ER stress response in Arabidopsis seeds.Protein-Specific Differential Glycosylation of Immunoglobulins in Serum of Ovarian Cancer Patients.A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins.Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities.Mono- and bivalent antibody fragments produced in Escherichia coli: engineering, folding and antigen binding.The James Blundell Award Lecture 2007: do we really understand immune red cell destruction?Synthesis and assembly of a full-length human monoclonal antibody in algal chloroplasts.
P2860
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P2860
Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and/or Fc gamma RII receptors.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@en
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@nl
type
label
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@en
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@nl
prefLabel
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@en
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@nl
P2093
P2860
P356
P1433
P1476
Aglycosylation of human IgG1 a ...... and/or Fc gamma RII receptors.
@en
P2093
P2860
P304
P356
10.1042/BJ2590347
P407
P577
1989-04-01T00:00:00Z