The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
about
X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia BStructural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor DThe crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.Crystal structure of the anticoagulant slow form of thrombinStaphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activationCrystal structure of the serine protease domain of prophenoloxidase activating factor-ICrystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4Structural identification of the pathway of long-range communication in an allosteric enzymeStructural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1Crystal structure of prethrombin-1Crystal Structures of Prethrombin-2 Reveal Alternative Conformations under Identical Solution Conditions and the Mechanism of Zymogen ActivationA Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of ActivationThe 2.8 A crystal structure of Gla-domainless activated protein CA serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism.Spontaneous proton transfer to a conserved intein residue determines on-pathway protein splicing.How Na+ activates thrombin--a review of the functional and structural data.Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrateDetecting Allosteric Networks Using Molecular Dynamics SimulationRatcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.Modeling zymogen protein C.Why Ser and not Thr brokers catalysis in the trypsin foldKinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand bindingHirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complexCrystal structure of recombinant human tissue kallikrein at 2.0 A resolutionActivation of alphaVbeta3 on vascular cells controls recognition of prothrombinEffect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.Incorporation of the fluorescent amino acid 7-azatryptophan into the core domain 1-47 of hirudin as a probe of hirudin folding and thrombin recognition.Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Thrombin.Deuterium solvent isotope effect and proton-inventory studies of factor Xa-catalyzed reactionsExosites in the substrate specificity of blood coagulation reactions.The transition of prothrombin to thrombin.DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations.Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence.
P2860
Q24562944-993643F9-468D-4F18-BD9D-160D4CCA0205Q27617260-2AD90289-3189-44EA-8E85-189D9D0BA039Q27637552-0E178883-066B-4F56-91EE-D1FE34208122Q27639560-DF37B9F0-B304-4882-B519-968437DDC814Q27642265-20D0EF84-5C4F-45AC-BE21-A1E336133999Q27643757-DD5B00BB-9B98-4C1D-89D7-F1DCCD93A21BQ27646532-247AFEAC-0A88-4C80-B15D-235C4123A24CQ27649783-7397BB98-3675-4CE4-AD03-D0D23A20F173Q27652199-B9DB7C24-CC38-42AC-B6C0-633BA960B58BQ27660263-8EB65B1F-AC25-4CF9-8837-899CBCE8F39CQ27665368-D15CC296-3C44-4262-BB28-1BEBBE595E74Q27675359-6FEF8476-04A6-4304-B31C-FABFCD3FC567Q27677421-327A7186-6AFA-46E0-A9F8-E4B0199E80A2Q27678654-C9F29816-0313-4793-BB3D-33D15933C787Q27734660-EBD29E23-29B7-4DD6-8AC7-F8F6A4F3393AQ30168478-B6AB8161-2B0D-4168-B21C-18D923AE02DDQ30498114-FA8E25B5-6455-4648-A114-CB2D8B032429Q33382168-4293B17A-41B8-4C04-AECA-3EC0CEE8B06CQ33581285-8D3E9E84-8D3E-41B1-BF5A-7F9A1551971EQ33858061-1B1ADC54-D3CF-46D0-9D1D-925C7AA86767Q33895760-CE690DE4-64BA-485D-BDBA-445955249F7AQ33911557-2410912C-963E-4925-8639-82ABD22E930EQ34041148-1BC9842E-ED23-4142-A4FE-370630E91ADDQ34174481-78A90A5F-44FE-40A1-AE14-6A5CAE4D7C60Q35127936-6A434842-DDCF-4B11-AC12-B94249F7B80BQ36049897-9A3492C2-6DEE-4CBC-9AC2-546064A1D6ABQ36279819-447D6B9C-5C16-4B1D-9745-B3C9125280D3Q36280463-48E021BF-734B-4FC6-8E1D-AD785DFB63E0Q36280837-C0036903-3490-4240-811F-D038E86CCFF2Q36280945-C236B881-94A5-4689-A4A7-59382EE83E30Q36328589-0CAE1EAD-6CB8-4002-AC82-E0ECF03A7A70Q36385980-EA932EE1-731E-4F13-9CF8-5786C6F9AB61Q36519387-41EE2A61-5929-4ADD-B951-0FC816B55E10Q36538526-F8ADD86C-DD26-4997-93D0-77560905B7E9Q36800534-311B2C43-C339-4A14-9903-DBB556DA763EQ36874076-EF587823-6CD1-41E3-A7B5-194B3B96269AQ36884329-51034919-8BFA-41C2-8061-B96343295772Q37019579-13B0C787-4F1F-4AAB-A768-55DD1109466AQ37069251-52D1DB5F-3070-478B-AB03-0CAA1AF6DF5BQ37253802-986D61A6-2D18-4321-A833-31FB54B2EBB5
P2860
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The isomorphous structures of ...... d exosite binding to thrombin.
@en
The isomorphous structures of ...... d exosite binding to thrombin.
@nl
type
label
The isomorphous structures of ...... d exosite binding to thrombin.
@en
The isomorphous structures of ...... d exosite binding to thrombin.
@nl
prefLabel
The isomorphous structures of ...... d exosite binding to thrombin.
@en
The isomorphous structures of ...... d exosite binding to thrombin.
@nl
P2093
P2860
P356
P1433
P1476
The isomorphous structures of ...... d exosite binding to thrombin.
@en
P2093
A Tulinsky
J Vijayalakshmi
K P Padmanabhan
P2860
P304
P356
10.1002/PRO.5560031211
P577
1994-12-01T00:00:00Z