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Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models.Methods for ECG evaluation of indicators of cardiac risk, and susceptibility to aconitine-induced arrhythmias in rats following status epilepticus.Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.Increased dietary sodium enhances activation of neurons in the medullary cardiovascular pathway during acute sodium loading in the rat.Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin II infusion.Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.Status epilepticus produces chronic alterations in cardiac sympathovagal balance.Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugsEvaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling modelEvaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats
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description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Cameron S Metcalf
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Cameron S Metcalf
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Cameron S Metcalf
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Cameron S Metcalf
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Cameron S Metcalf
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type
label
Cameron S Metcalf
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Cameron S Metcalf
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Cameron S Metcalf
@es
Cameron S Metcalf
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Cameron S Metcalf
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Cameron S Metcalf
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Cameron S Metcalf
@en
Cameron S Metcalf
@es
Cameron S Metcalf
@nl
Cameron S Metcalf
@sl
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0000-0002-1510-0405