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Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitisHost-microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseCommon variants at five new loci associated with early-onset inflammatory bowel diseaseGenome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility lociHeterogeneity of the gut microbiome in mice: guidelines for optimizing experimental designMetallothionein and stress combine to affect multiple organ systemsResequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel diseaseNovel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview.Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent.Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment.Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease.Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy.Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's diseaseCARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's diseaseAltered gut transcriptome in spondyloarthropathyInterindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25-3T studied in an in vitro gut model.Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potentialThe Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE MicePlacental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma.Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure.Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controlsEvidence for a potential role of metallothioneins in inflammatory bowel diseases.Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis.Novel development in extraintestinal manifestations and spondylarthropathy.The paradox of the unfolded protein response in cancer.Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis.T84 monolayers are superior to Caco-2 as a model system of colonocytes.A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.Detection and Manipulation of the Stress Response Protein Metallothionein.Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.Validated High Resolution Mass Spectrometry-Based Approach for Metabolomic Fingerprinting of the Human Gut Phenotype.Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity.Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma.Role of metallothioneins as danger signals in the pathogenesis of colitis.Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis.
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Debby Laukens
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Debby Laukens
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Debby Laukens
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Debby Laukens
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Debby Laukens
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Debby Laukens
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Debby Laukens
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P106
P21
P31
P496
0000-0002-1984-5850