about
Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cellsDifferences between the catalytic properties of recombinant human PC2 and endogenous rat PC2Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetesThe human insulin gene linked polymorphic region exhibits an altered DNA structureSulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide (IAPP) promotersSex steroid regulation of glutamate decarboxylase mRNA expression in goldfish brain is sexually dimorphic.Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.Gamma-aminobutyric acid up-regulates the expression of a novel secretogranin-II messenger ribonucleic acid in the goldfish pituitary.An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes.Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreasPancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.Presence of endocrine and exocrine markers in EGFP-positive cells from the developing pancreas of a nestin/EGFP mouse.Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes.Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture.Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells.Comparative analysis of insulin gene promoters: implications for diabetes research.Embryonic stem cell therapy for diabetes mellitus.Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells.Metabolic control of insulin gene expression and biosynthesis.Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the ovine PrP (Prion) gene promoter.Stem cells and metabolic diseases.Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell.Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytesA comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones.Identification of a 31,500 molecular weight islet cell protease as cathepsin B.Cell therapy for type 1 diabetes.Identification and characterization of a functional retinoic acid/thyroid hormone-response element upstream of the human insulin gene enhancerAssociation of prohormone convertase 3 with membrane lipid rafts.Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.The gel retardation assay.The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer.Human insulin gene enhancer-binding proteins in pancreatic alpha and beta cell lines.Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.Two proteins act as the IUF1 insulin gene enhancer binding factor.The effects of ions and pH on the transport of sugars into rat liver lysosomes.Ionic effects on the transport of sugars in rat liver lysosomes [proceedings]
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Kevin Docherty
@ast
Kevin Docherty
@en
Kevin Docherty
@es
Kevin Docherty
@nl
Kevin Docherty
@sl
type
label
Kevin Docherty
@ast
Kevin Docherty
@en
Kevin Docherty
@es
Kevin Docherty
@nl
Kevin Docherty
@sl
prefLabel
Kevin Docherty
@ast
Kevin Docherty
@en
Kevin Docherty
@es
Kevin Docherty
@nl
Kevin Docherty
@sl
P108
P106
P1153
7006117727
P21
P31
P496
0000-0001-6765-2060