about
DNA damage by histone radicals in nucleosome core particlesProbing interactions between lysine residues in histone tails and nucleosomal DNA via product and kinetic analysis.Histone modification via rapid cleavage of C4'-oxidized abasic sites in nucleosome core particles.Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.Why Carba-LNA-modified oligonucleotides show considerably improved 3'-exonuclease stability compared to that of the LNA modified or the native counterparts: A Michaelis-Menten kinetic analysis.Synthesis of 2',4'-propylene-bridged (carba-ENA) thymidine and its analogues: the engineering of electrostatic and steric effects at the bottom of the minor groove for nuclease and thermodynamic stabilities and elicitation of RNase H.Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide.5-Formylcytosine Yields DNA-Protein Cross-Links in Nucleosome Core Particles.Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones.Synthesis and biological applications of fluoro-modified nucleic acids.Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.Oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine leads to substantial DNA-histone cross-links within nucleosome core particlesBasis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome4'-Fluorinated RNA: Synthesis, Structure, and Applications as a Sensitive 19F NMR Probe of RNA Structure and FunctionCysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolonesNitrogen Mustard Induces Formation of DNA-Histone Cross-Links in Nucleosome Core ParticlesEffect of Ribose Conformation on RNA Cleavage via Internal TransesterificationA light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugatesTransesterification Reaction and the Repair of Embedded Ribonucleotides in DNA Are Suppressed upon the Assembly of DNA into Nucleosome Core Particles †
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Chuanzheng Zhou
@ast
Chuanzheng Zhou
@en
Chuanzheng Zhou
@es
Chuanzheng Zhou
@nl
Chuanzheng Zhou
@sl
type
label
Chuanzheng Zhou
@ast
Chuanzheng Zhou
@en
Chuanzheng Zhou
@es
Chuanzheng Zhou
@nl
Chuanzheng Zhou
@sl
prefLabel
Chuanzheng Zhou
@ast
Chuanzheng Zhou
@en
Chuanzheng Zhou
@es
Chuanzheng Zhou
@nl
Chuanzheng Zhou
@sl
P106
P31
P496
0000-0002-0811-7794