Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis.
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Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatisNew agents for the treatment of drug-resistant Mycobacterium tuberculosisLearning from the past for TB drug discovery in the futureStructural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosisCrystal structure of decaprenylphosphoryl-β-D-ribose 2'-epimerase fromMycobacterium smegmatisStructural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitorsTowards a new combination therapy for tuberculosis with next generation benzothiazinonesIn Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis[Better search strategies, hopeful candidates. The search for new antimycobacterial drugs].Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification StrategyThe cell envelope glycoconjugates of Mycobacterium tuberculosisYeast three-hybrid screening for identifying anti-tuberculosis drug targets.Pseudomonas aeruginosa D-arabinofuranose biosynthetic pathway and its role in type IV pilus assembly.Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone.In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatmentImportance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistanceIdentification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.Thiolates chemically induce redox activation of BTZ043 and related potent nitroaromatic anti-tuberculosis agentsProgress in targeting cell envelope biogenesis in Mycobacterium tuberculosis.Developing pyrrole-derived antimycobacterial agents: a rational lead optimization approach.Tuberculosis drugs: new candidates and how to find more.Challenges and opportunities in developing novel drugs for TB.Antituberculars which target decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1: state of art.Antituberculosis drug research: a critical overview.Targeting the mycobacterial envelope for tuberculosis drug development.Prospects for new antibiotics: a molecule-centered perspective.The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis.Future target-based drug discovery for tuberculosis?The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan.The anti-tuberculosis agents under development and the challenges ahead.Identification of Better Pharmacokinetic Benzothiazinone Derivatives as New Antitubercular Agents.Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.Drug Resistance Mechanisms in Mycobacterium tuberculosis.Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity.Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis.In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis.Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Metabolism of SKLB-TB1001, a Potent Antituberculosis Agent, in Animals.
P2860
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P2860
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@en
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@nl
type
label
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@en
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@nl
prefLabel
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@en
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@nl
P2093
P356
P1476
Benzothiazinones: prodrugs tha ...... of Mycobacterium tuberculosis.
@en
P2093
Claudia Trefzer
Marlon J Hinner
Monica Rengifo-Gonzalez
Patricia Schneider
Stewart T Cole
Vadim Makarov
P304
13663-13665
P356
10.1021/JA106357W
P407
P50
P577
2010-10-01T00:00:00Z