Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.
about
PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cellsA drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell typesThiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.Detection and manipulation of phosphoinositides.Drugging the PI3 kinome: from chemical tools to drugs in the clinic.Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3KβSelective PI3Kδ inhibitors, a review of the patent literature.Prodrug strategy for PSMA-targeted delivery of TGX-221 to prostate cancer cells.Mechanistic insights into a novel chromone-appended Cu(II) anticancer drug entity: in vitro binding profile with DNA/RNA substrates and cytotoxic activity against MCF-7 and HepG2 cancer cells.Definition of the binding mode of phosphoinositide 3-kinase α-selective inhibitor A-66S through molecular dynamics simulation.
P2860
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P2860
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@en
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@nl
type
label
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@en
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@nl
prefLabel
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@en
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@nl
P2093
P2860
P50
P356
P1433
P1476
Dissecting isoform selectivity ...... idues in the catalytic pocket.
@en
P2093
Cenk Suphioglu
Ian G Jennings
Jiuxiang Zhu
Mark Frazzetto
Oleg Schmidt-Kittler
Shaun P Jackson
Susan L Cranmer
P2860
P304
P356
10.1042/BJ20080512
P407
P577
2008-09-01T00:00:00Z