Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action.
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Artemisinin-resistant malaria: research challenges, opportunities, and public health implicationsA Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of ChloroquineImplications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and ArtemisininNovel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activitiesReactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.Artemisone uptake in Plasmodium falciparum-infected erythrocytes.The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malariaArtemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malariaExamination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarialsArtemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsSynthesis of a potent antimalarial agent through natural products conjugation.Targeting apicoplasts in malaria parasites.Quantification of dihydroartemisinin, artesunate and artemisinin in human blood: overcoming the technical challenge of protecting the peroxide bridge.Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins.Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.Methylene blue and its analogues as antidepressant compounds.Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity.Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.Electrostatic Modification for Promotion of Flavin-Mediated Oxidation of a Probe for Flavin Detection.Methylene Blue as a Photosensitizer and Redox Agent: Synthesis of 5-Hydroxy-1H-pyrrol-2(5H)-ones from Furans.Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice.Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum.Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation.Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte StagesSecond generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activitiesEfficient Synthesis of 3,5-Dicarbamoyl-1,4-dihydropyridines from Pyridinium Salts: Key Molecules in Understanding NAD(P)+/NAD(P)H Pathways
P2860
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P2860
Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@en
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@nl
type
label
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@en
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@nl
prefLabel
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@en
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@nl
P2093
P921
P356
P1433
P1476
Facile oxidation of leucomethy ...... imalarial mechanism of action.
@en
P2093
Davide Prosperi
Diego Monti
Herman H Y Sung
Ho-Ning Wong
Kit-Man Fan
Paolo Coghi
Sergio Melato
Wai-Keung Wu
Wing-Chi Chan
P2860
P304
P356
10.1002/CMDC.201000225
P577
2010-08-01T00:00:00Z