N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface.
about
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.Mutation of a conserved hydrophobic patch prevents incorporation of ZP3 into the zona pellucida surrounding mouse eggsLoss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and NeurodegenerationCritical roles of nardilysin in the maintenance of body temperature homoeostasisNardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains.Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.
P2860
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P2860
N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-cn
2000年学术文章
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2000年学术文章
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2000年學術文章
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name
N-arginine dibasic convertase ...... plasm and at the cell surface.
@en
N-arginine dibasic convertase
@nl
type
label
N-arginine dibasic convertase ...... plasm and at the cell surface.
@en
N-arginine dibasic convertase
@nl
prefLabel
N-arginine dibasic convertase ...... plasm and at the cell surface.
@en
N-arginine dibasic convertase
@nl
P2093
P2860
P1433
P1476
N-arginine dibasic convertase ...... plasm and at the cell surface.
@en
P2093
P2860
P304
P356
10.1042/0264-6021:3490587
P407
P577
2000-07-01T00:00:00Z