Genome sequencing of normal cells reveals developmental lineages and mutational processes. - Wikidata - wikimedia - TriplyDB

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

http://www.wikidata.org/entity/Q42997512

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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy Single-cell sequencing in stem cell biology Organoid Models of Human Gastrointestinal Development and Disease A metabolic perspective of Peto's paradox and cancer Somatic mosaicism: implications for disease and transmission genetics Mutational signatures associated with tobacco smoking in human cancer The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals Genetic mosaics and the germ line lineage Accuracy of Answers to Cell Lineage Questions Depends on Single-Cell Genomics Data Quality and Quantity Human Germline Mutation and the Erratic Evolutionary Clock The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning.Findings made in gene panel to whole genome sequencing: data, knowledge, ethics - and consequences?MosaicHunter: accurate detection of postzygotic single-nucleotide mosaicism through next-generation sequencing of unpaired, trio, and paired samples.Systematic comparison of two whole-genome amplification methods for targeted next-generation sequencing using frozen and FFPE normal and cancer tissues.Single-cell genome sequencing: current state of the science.Somatic mutation in single human neurons tracks developmental and transcriptional history Whole-organism lineage tracing by combinatorial and cumulative genome editing Origin of cells and network information Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts A new conceptual framework for investigating complex genetic disease.Building a lineage from single cells: genetic techniques for cell lineage tracking.Differences in the rare variant spectrum among human populations.Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis-generating study.Clock-like mutational processes in human somatic cells.A mutational signature in gastric cancer suggests therapeutic strategies The Role of Constitutional Copy Number Variants in Breast Cancer.Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism Analysis of tumor template from multiple compartments in a blood sample provides complementary access to peripheral tumor biomarkers When Should Genetic Testing Be Performed in Epilepsy Patients?From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells.Using tumour phylogenetics to identify the roots of metastasis in humans.The origins, determinants, and consequences of human mutations.Somatic mutation in cancer and normal cells.A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.

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Genome sequencing of normal cells reveals developmental lineages and mutational processes.

http://www.wikidata.org/entity/Q42997512

description

2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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2014年學術文章

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name

Genome sequencing of normal ce ...... ages and mutational processes.

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Genome sequencing of normal ce ...... ages and mutational processes.

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type

label

Genome sequencing of normal ce ...... ages and mutational processes.

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Genome sequencing of normal ce ...... ages and mutational processes.

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prefLabel

Genome sequencing of normal ce ...... ages and mutational processes.

@en

Genome sequencing of normal ce ...... ages and mutational processes.

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Genome sequencing of normal ce ...... ages and mutational processes.

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Ben Robinson

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Edwin Cuppen

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Gunes Gundem

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Hans Clevers

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Inigo Martincorena

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Joyce Blokker

http://www.w3.org/2001/XMLSchema#string

Laura Mudie

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Marc van de Wetering

http://www.w3.org/2001/XMLSchema#string

Mark Maddison

http://www.w3.org/2001/XMLSchema#string

Meritxell Huch

http://www.w3.org/2001/XMLSchema#string

P2860

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Mutational processes molding the genomes of 21 breast cancers

Somatic mutations in aging, cancer and neurodegeneration

Identification of stem cells in small intestine and colon by marker gene Lgr5

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Deciphering signatures of mutational processes operative in human cancer

Signatures of mutational processes in human cancer

The life history of 21 breast cancers

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

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10.1038/NATURE13448

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513

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Serena Nik-Zainal

Ruben van Boxtel

Ludmil B. Alexandrov

Michael Stratton

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