Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis.
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New developments in the genetics, pathogenesis, and therapy of IgA nephropathyModulatory effects of bortezomib on host immune cell functionsImmunoproteasomes: structure, function, and antigen presentationA key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functionsBoosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In VivoAstragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolismImpairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.Proteasome inhibitor bortezomib ameliorates intestinal injury in mice.The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexesDiscovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environmentProgression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genesEnhanced inflammatory potential of CD4+ T-cells that lack proteasome immunosubunit expression, in a T-cell transfer-based colitis model.Immunoproteasome deficiency protects in the retina after optic nerve crush.Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal PneumoniaSubunit specific inhibitors of proteasomes and their potential for immunomodulationA selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice.Mir-451 Correlates with Prognosis of Renal Cell Carcinoma Patients and Inhibits Cellular Proliferation of Renal Cell CarcinomaProbiotics increase T regulatory cells and reduce severity of experimental colitis in miceAstragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer's patches.Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice.Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis.Current understanding on the role of standard and immunoproteasomes in inflammatory/immunological pathways of multiple sclerosis.The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cellsInhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.Proteasome inhibitors: an expanding army attacking a unique target.Emerging roles of immunoproteasomes beyond MHC class I antigen processing.Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 AxisModulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity.Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.MiR-451 suppresses cell proliferation and metastasis in A549 lung cancer cells.Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells.Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases.The immunoproteasome: An old player with a novel and emerging role in alloimmunity.An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling.Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7.The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.Cytokine-induced oxidative stress in cardiac inflammation and heart failure-how the ubiquitin proteasome system targets this vicious cycleTranscription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells.
P2860
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P2860
Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Targeting the proteasome: part ...... tenuates experimental colitis.
@en
Targeting the proteasome: part ...... tenuates experimental colitis.
@nl
type
label
Targeting the proteasome: part ...... tenuates experimental colitis.
@en
Targeting the proteasome: part ...... tenuates experimental colitis.
@nl
prefLabel
Targeting the proteasome: part ...... tenuates experimental colitis.
@en
Targeting the proteasome: part ...... tenuates experimental colitis.
@nl
P2093
P50
P356
P1433
P1476
Targeting the proteasome: part ...... tenuates experimental colitis.
@en
P2093
Anja A Kühl
Erik Gonzalez
Hans Mollenkopf
Nicole Schmidt
Thorsten Joeris
P304
P356
10.1136/GUT.2009.203554
P407
P577
2010-07-01T00:00:00Z