about
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphismStimulation of DNA synthesis and cell proliferation of human mammary myoepithelial-like cells by hepatocyte growth factor/scatter factor depends on heparan sulfate proteoglycans and sustained phosphorylation of mitogen-activated protein kinases p42/The mode of action of heparan and dermatan sulfates in the regulation of hepatocyte growth factor/scatter factorHepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfateA new map of glycosaminoglycan and C3b binding sites on factor HDisease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structurePatterns of sulphation in heparan sulphate: polymorphism based on a common structural themeThe molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouseDMT-MM mediated functionalisation of the non-reducing end of glycosaminoglycans.Quantitative and qualitative alterations of heparan sulfate in fibrogenic liver diseases and hepatocellular cancerThe interaction of the transforming growth factor-betas with heparin/heparan sulfate is isoform-specific.Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy.Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes.Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies.The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.Interaction of human β-defensin 2 (HBD2) with glycosaminoglycans.Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns.A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin/dermatan sulfates from biological samples.Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration.Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation.The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue.Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.A rapid purification of bovine testicular hyaluronidase by chromatography on dermatan sulphate-substituted 1,6-diaminohexane--sepharose 4B.Isolation and characterization of the integral glycosaminoglycan constituents of human amyloid A and monoclonal light-chain amyloid fibrils.The synthesis of proteoglycans by human T lymphocytes.Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.Residual dipolar coupling investigation of a heparin tetrasaccharide confirms the limited effect of flexibility of the iduronic acid on the molecular shape of heparin.Highly sensitive sequencing of the sulfated domains of heparan sulfate.Heparan sulphate-degrading endoglycosidase in liver plasma membranesIsolation and characterization of high-buoyant-density proteoglycans from bovine femoral-head cartilage.Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan.A new model for the domain structure of heparan sulfate based on the novel specificity of K5 lyase.Distinct substrate specificities of bacterial heparinases against N-unsubstituted glucosamine residues in heparan sulfate.Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro.Specific chemical modifications of link protein and their effect on binding to hyaluronate and cartilage proteoglycan.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Malcolm Lyon
@ast
Malcolm Lyon
@en
Malcolm Lyon
@es
Malcolm Lyon
@nl
Malcolm Lyon
@sl
type
label
Malcolm Lyon
@ast
Malcolm Lyon
@en
Malcolm Lyon
@es
Malcolm Lyon
@nl
Malcolm Lyon
@sl
prefLabel
Malcolm Lyon
@ast
Malcolm Lyon
@en
Malcolm Lyon
@es
Malcolm Lyon
@nl
Malcolm Lyon
@sl
P106
P21
P31
P496
0000-0001-9575-6879
P569
2000-01-01T00:00:00Z