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A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.Preparation, pharmacokinetics, biodistribution, antitumor efficacy and safety of Lx2-32c-containing liposomeOn the chemical constituents of Dipsacus asper.Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer.Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.Microtubule stabilising agents for cancer chemotherapy.Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo.Structural studies of taxol analogues for drug discovery.Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates.Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo.Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo.Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells.Three new antioxidant C-glucosylanthrones from Aloe nobilis.Biotransformation of 3-oxo-oleanolic acid by Absidia glauca.BACE1 (beta-secretase) inhibitory phenolic acids and a novel sesquiterpenoid from Homalomena occulta.Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses.New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis.Distribution of paclitaxel and its congeners in Taxus mairei.Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation.A new triglucosylated naphthalene glycoside from Aloe vera L.Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck.An efficient semi-synthesis and structure revision of a cytotoxic triterpenoid 25-acetoxy-3alpha-hydroxyolean-12-en-28-oic acid from Liquidamber styraciflua.Jacaranone analogs from Senecio scandens.Synthesis and biological activities of high affinity taxane-based fluorescent probes.BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis.Anti-tumor activity of a 3-oxo derivative of oleanolic acid.A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility.Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods.Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative.A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization.Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.Design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives.Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analoguesTwo novel tetrairidoid glucosides from Dipsacus asper
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onderzoeker
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հետազոտող
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Wei-Shuo Fang
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Wei-Shuo Fang
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P106
P1153
35304847800
P31
P496
0000-0002-0972-0640