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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases.Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays.A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicityAllosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases.Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases.Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity.Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Src family kinases and their role in hematological malignancies.A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity.A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies.The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate.A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases.Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.Regulation and function of protein kinases and phosphatases.Decreased CHK protein levels are associated with Src activation in colon cancer cells.Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase.C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.Dual role of Src kinase in governing neuronal survival.Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).Differential in vitro phosphorylation of clathrin light chains by the epidermal growth factor receptor-associated protein tyrosine kinase and a pp60c-src-related spleen tyrosine kinase.Activation of Src family tyrosine kinases by ferric ions.Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide.Common in vitro substrate specificity and differential Src homology 2 domain accessibility displayed by two members of the Src family of protein-tyrosine kinases, c-Src and Hck.PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinasesModulation of the Catalytic Activity of the Src Family Tyrosine Kinase Hck by Autophosphorylation at a Novel Site in the Unique Domain1H, 13C and 15N chemical shift assignments of the SH2 domain of the Csk homologous kinaseA Peptide Corresponding to Residues Asp177 to Asn208 of Human Cyclin A Forms an α-HelixThe Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase propertiesCsk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Heung-Chin Cheng
@ast
Heung-Chin Cheng
@en
Heung-Chin Cheng
@es
Heung-Chin Cheng
@nl
Heung-Chin Cheng
@sl
type
label
Heung-Chin Cheng
@ast
Heung-Chin Cheng
@en
Heung-Chin Cheng
@es
Heung-Chin Cheng
@nl
Heung-Chin Cheng
@sl
prefLabel
Heung-Chin Cheng
@ast
Heung-Chin Cheng
@en
Heung-Chin Cheng
@es
Heung-Chin Cheng
@nl
Heung-Chin Cheng
@sl
P106
P1153
7404285050
P31
P496
0000-0002-4965-7148