Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
about
E-type prostanoid receptor 4 (EP4) in disease and therapyProstaglandin EP4 antagonists.Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain.AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesiaEvaluation of a candidate anti-arthritic drug using the mouse collagen antibody induced arthritis model and clinically relevant biomarkers.Signalling transduction events involved in agonist-induced PGE2/EP4 receptor externalization in cultured rat dorsal root ganglion neurons.Visible Light Photoredox Catalyzed Cascade Cyclizations of α-Bromochalcones or α-Bromocinnamates with Heteroarenes
P2860
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P2860
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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name
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@en
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@nl
type
label
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@en
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@nl
prefLabel
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@en
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@nl
P2093
P1476
Discovery of 4-[1-[([1-[4-(tri ...... or treating inflammatory pain.
@en
P2093
Alex G Therien
Carl Berthelette
Danielle Denis
Jean-Francois Chiasson
Jean-Francois Levesque
John Colucci
Marie-Claude Mathieu
Mark Wrona
Michael Boyd
P304
P356
10.1016/J.BMCL.2010.04.065
P407
P577
2010-04-18T00:00:00Z