Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.
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How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopyPermeation, regulation and control of expression of TRP channels by trace metal ionsIntrinsic properties and regulation of Pannexin 1 channel.Principles and properties of ion flow in P2X receptorsStructure of the full-length TRPV2 channel by cryo-EM.Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicityXanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20Physical basis of apparent pore dilation of ATP-activated P2X receptor channelsLocal mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analogEffect of cholesterol depletion on the pore dilation of TRPV1.Irritating channels: the case of TRPA1.P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.The dynamic TRPA1 channel: a suitable pharmacological pain target?Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings.Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cationsTRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells.Fiber-optic control and thermometry of single-cell thermosensation logicA structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.The Outer Pore and Selectivity Filter of TRPA1Cellular permeation of large molecules mediated by TRPM8 channels.Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain.TRP channels.Transient receptor potential ankyrin 1 (TRPA1) antagonists.TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.Measurement of relative Ca²⁺ permeability during sustained activation of TRPV1 receptors.Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.Pore dilation reconsideredCharacterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore.Quantitative Limits on Small Molecule Transport via the Electropermeome - Measuring and Modeling Single Nanosecond Perturbations.TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity.Agonist-induced sensitisation of the irritant receptor ion channel TRPA1.Contributions of space-clamp errors to apparent time-dependent loss of Mg2+ block induced by NMDA.A novel TRPA1 variant is associated with carbamazepine-responsive cramp-fasciculation syndrome.
P2860
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P2860
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@en
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@nl
type
label
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@en
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@nl
prefLabel
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@en
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@nl
P2093
P2860
P1476
Dynamic changes in the TRPA1 s ...... but reversible pore dilation.
@en
P2093
A D Wickenden
S R Chaplan
P2860
P304
P356
10.1152/AJPCELL.00489.2009
P577
2010-03-24T00:00:00Z