about
The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia.Structural Characterisation of Ligand-Binding Determinants in Human Lung Surfactant Protein D: Influence of Asp325Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells.Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient miceThe genetics of neonatal respiratory disease.Recent advances in alveolar biology: evolution and function of alveolar proteins.Untapped therapeutic potential of surfactant proteins: is there a case for recombinant SP-D supplementation in neonatal lung disease?Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis.Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin.The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms.Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor.Surfactant protein D (SP-D) alters cellular uptake of particles and nanoparticles.Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D.Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells.Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D.Surfactant and lung inflammation.Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy.Surfactant protein D (SP-D) deficiency is attenuated in humanised mice expressing the Met(11)Thr short nucleotide polymorphism of SP-D: implications for surfactant metabolism in the lung.A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema.Surfactant protein D binds genomic DNA and apoptotic cells, and enhances their clearance, in vivo.A recombinant fragment of human SP-D reduces allergic responses in mice sensitized to house dust mite allergens.Intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy.Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes.Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D.Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS.Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens of Aspergillus fumigatusEvaluation of Full-length, Cleaved and Nitrosylated Serum Surfactant Protein D as Biomarkers for COPDThe lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammationHelicobacter infection in the surfactant protein D-deficient mouseA recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient miceSusceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosisIncreased prevalence of low oligomeric state surfactant protein D with restricted lectin activity in bronchoalveolar lavage fluid from preterm infants
P50
Q24816691-5ABC1AC9-9945-41CB-B29D-0BBF7C5C85ABQ27657642-10491697-4F7E-41C8-AA87-D14FFF3149FDQ34634567-CC036CB1-0A22-46CA-A4EE-F4458A5D3935Q36145590-9CFC1121-C127-4E9E-954E-9CF90E248DB3Q36146418-2A704EF1-44BB-47BA-8FDE-872F95A5BDD5Q37740275-1B634066-1CDD-4E16-906D-B574B4C882A5Q37765431-0BF95F7E-AE95-4BD1-A681-65DAA3FDA58FQ38311971-B3C10288-3C0F-49D0-AF0F-30CAA3AD8BEBQ38341128-336CD394-3112-4ED3-9F4C-F904DA59FE35Q38349220-B3381434-1405-457B-842A-02AE52CEC305Q39032467-56A0C158-BADA-4F48-8D0E-1B65421F695AQ39355230-21439421-5158-414A-BF82-7C3AEA75B29DQ39884624-2F0AFD16-2CFF-489A-BBE3-0F3AB62E8D3BQ41968902-F914792A-A352-49DB-98ED-4D938B046656Q41977356-8C313F8D-7B3E-486A-BDE4-08FF7FE91CEAQ43058556-2D061CEA-EE50-49FF-B828-51F1C0EA1B30Q44233903-505ECA1B-252F-4620-8182-CEF90CFEDEB8Q44765093-BBB2B7C8-9247-41B9-B663-18B47DD3A2A7Q44807189-BFBF4B40-9611-45C5-B05E-9E24F5A2859DQ47916772-7D7B9A77-19BF-42AD-B2A8-53D87B876A9EQ51643864-38970012-E55A-407A-A664-499A86ED6DBAQ51680884-F26452B2-1457-4083-A935-3F99ED7F4B45Q53252311-352B8C9F-543A-4515-84FF-B06E3808E746Q53528647-844F0AE6-1AE7-4984-9ADD-1FBE72A05F51Q55478327-10D356BA-F386-4915-B892-E760A2515AE0Q56655896-5FD18359-C090-4F9D-94E1-84667392F548Q58967109-2CF7156D-CBA5-4C2D-9F7E-EC6EEA7CD37FQ64450801-B9BA37D2-A441-497A-B0BD-6FC1BC8112F3Q79798185-64A845BF-4EB7-48AE-81C2-6D39B941588FQ83258787-57FFA7F6-C1C5-4F31-9D70-C2AF41571CEAQ84096217-A9617BF9-18BE-411B-A0B6-614BF6C60405Q86077331-BF214701-95BF-4F1B-AEE3-D3DF3CE25F54
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Howard Clark
@ast
Howard Clark
@en
Howard Clark
@es
Howard Clark
@nl
Howard Clark
@sl
type
label
Howard Clark
@ast
Howard Clark
@en
Howard Clark
@es
Howard Clark
@nl
Howard Clark
@sl
prefLabel
Howard Clark
@ast
Howard Clark
@en
Howard Clark
@es
Howard Clark
@nl
Howard Clark
@sl
P106
P1153
7202405777
P21
P31
P496
0000-0001-7354-2028