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Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridolNovel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae).Iminosugars as therapeutic agents: recent advances and promising trends.4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors.Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.Calystegins of Physalis alkekengi var. francheti (Solanaceae). Structure determination and their glycosidase inhibitory activities.Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.Two subsites on the active center of pig kidney trehalase.Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer.Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes.Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae).Glucosylceramide mimics: highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types 1 and 2 Gaucher disease.Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents.In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.1-O-Benzyl-2,3-O-iso-propyl-idene-6-O-tosyl-α-l-sorbo-furan-ose.Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.).2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease.Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid.Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors.Dihydroxynortropane alkaloids from calystegine-producing plants.Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes.New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii.The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases.Alkaloids from the poisonous plant Ipomoea carnea: effects on intracellular lysosomal glycosidase activities in human lymphoblast cultures.C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.General synthesis and biological evaluation of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides).General synthesis of sugar-derived azepane nitrones: precursors of azepane iminosugars.Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.Mechanical allodynia induced by paclitaxel, oxaliplatin and vincristine: different effectiveness of gabapentin and different expression of voltage-dependent calcium channel alpha(2)delta-1 subunit.Effects of the prostaglandin E1 analog limaprost on mechanical allodynia caused by chemotherapeutic agents in mice.Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases.Biological properties of D- and L-1-deoxyazasugars.An approach to 8 stereoisomers of homonojirimycin from (D)-glucose via kinetic & thermodynamic azido-γ-lactones.Protective effects of dietary 1,5-anhydro-D-glucitol as a blood glucose regulator in diabetes and metabolic syndrome.
P50
Q27683682-0C5EC664-B62F-4B35-9680-1145900C2CA5Q31713775-D98B6CCB-88E9-4A6A-8456-08F3A3780E55Q34212463-E444E1E3-6038-4238-9460-F0393A5E556FQ34398684-E65D1563-F083-4E81-9B54-4176947D8DF6Q34459225-94994A4D-9EB9-413A-A629-8CC010D80E68Q34655757-26867A56-16AA-416D-81FE-D5E7D5751B99Q35296367-47BE4633-A2DF-43D2-9F68-B8C370E5E725Q35542016-40ED13AD-F7EE-4B74-B785-29AF95496A17Q35956223-0FF43A6D-FBB2-4C8F-951D-AB2B69E77D5DQ36703162-D131047D-BC48-4EAE-A650-22EC7B50DEB0Q37340035-E6DCAA65-C791-4589-B706-9CE50078E7F1Q38353031-BF470F89-95F6-48F7-AA3E-E8A0E2F75BF6Q38775176-877C8F21-610A-4DC9-A32A-DAFCF2337761Q38794391-E2DC7E48-5126-476B-88EF-507100D9590DQ39013090-766AEE73-2940-4758-B120-53F7A26AA0F0Q39046077-1043C4CC-C86C-4744-91E5-4CAF0675090EQ39081905-1CAE10DF-74C3-4DCA-96AD-AB23F7427E13Q39921713-61722FCF-0CEB-491B-9248-E447900FC733Q39966135-F388BCBC-F7A9-44D7-8F8D-7469BE249AABQ40241868-8082A682-2AC7-4D38-A783-B4183FE4883CQ41996561-D86113D7-D01B-45C8-9F1A-C027F609ECF4Q42053301-5F5F345D-6D00-41D6-AE8C-FD0AC93148E9Q43067252-8B7BFC79-D63E-4246-A6DD-0C0841AD5565Q43076224-641512B8-082C-409F-9897-FB1A6105E327Q43414466-8409C2D7-6EB9-48E5-8DFF-62606C7E93C9Q43633428-75AC9F95-B8B4-4373-9165-C54C71C8B4C5Q43742208-115A2CDF-8943-4EF5-9654-EF0D6523354AQ43891442-50D0DB17-3100-4F5E-BBF6-91103D9BB06DQ44410246-1BD70A05-509C-4BB5-8040-FC466BC2BA99Q44685856-CC0E6411-5549-46EB-912B-F8119C309624Q45065343-1828B055-ECD8-42CF-AD9A-4D301EF21C9CQ45280262-534D52BC-157F-4A3B-A6A4-CEB21D4166A5Q45893419-084779A1-EAE5-4FE8-ACE7-79CD10DE8320Q46046488-E6AA3EBB-A791-4346-9F5E-0056689A646EQ46066472-1FA33AE2-8797-4AA0-AE74-FF4573C82441Q46092869-2E1E8418-2D1C-45EB-8F2A-F17BB7107132Q46317235-3AEB78E3-CB17-4E4E-BC9A-A088D8783B93Q46383102-E1DB8D5A-207C-4A15-A0CF-A3797F09A01DQ46394636-93711A58-F347-4C8D-99A9-B0094479AB1BQ46412369-75BCA828-639A-4240-AE9E-6826A8333287
P50
description
researcher ORCID: 0000-0001-8022-196X
@en
wetenschapper
@nl
name
Atsushi Kato
@ast
Atsushi Kato
@en
Atsushi Kato
@es
Atsushi Kato
@nl
type
label
Atsushi Kato
@ast
Atsushi Kato
@en
Atsushi Kato
@es
Atsushi Kato
@nl
prefLabel
Atsushi Kato
@ast
Atsushi Kato
@en
Atsushi Kato
@es
Atsushi Kato
@nl
P106
P21
P31
P496
0000-0001-8022-196X
P569
2000-01-01T00:00:00Z