Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.
about
Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal CortexImpact of partial dopamine depletion on cognitive flexibility in BDNF heterozygous mice.Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5Acute inhibition of mGluR5 disrupts behavioral flexibility.Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction.Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer 18F-FPEB in human brain.A preregistered, direct replication attempt of the retrieval-extinction effect in cued fear conditioning in rats.
P2860
Q30595720-3D940C69-A6C4-48EB-85C1-EA10D91E6B84Q33671679-6117B444-457B-4BD4-8F19-EFB8DBF71A3AQ34399823-22B377FD-90BD-4069-B89B-A562B3FFF046Q35867117-A25FE072-EB9F-4086-80FD-2C650C33A92DQ36746407-1526FDF2-0B0D-4656-A146-26AFEB2595B9Q38669576-EFA89694-5E68-4ADC-8E89-FD335EA8E044Q38966204-2EC6D300-7E0F-42CC-8DC0-F881E3E471E5Q40096876-0E013B3C-64A9-41CE-89A4-B4B9D4328B50Q41846131-87B61698-A574-47EF-AF3F-E27493B9D7B5Q47970224-6C197D5B-6551-4088-A5C9-187A16B4C317Q48955944-D02488A0-8B74-4EE0-9FAC-80D3ACD3F98FQ50431213-741A1EF9-69C9-47B6-B03F-F37658AEC4B6
P2860
Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@en
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@nl
type
label
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@en
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@nl
prefLabel
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@en
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@nl
P2093
P2860
P50
P356
P1433
P1476
Potentiating mGluR5 function w ...... or enhances adaptive learning.
@en
P2093
John J Marshall
Qionger He
Shaun R Stauffer
Stephen Kraniotis
Toshihiro Nomura
Yongling Zhu
P2860
P304
P356
10.1101/LM.031666.113
P577
2013-07-18T00:00:00Z