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Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune ReceptorsReport from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.Sulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognitionIncreased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus ClearanceAbacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responsesMolecular basis of drug recognition by specific T-cell receptors.Delayed allergy-like reactions to X-ray contrast media: mechanistic considerations.Peptide vaccines against hepatitis B virus: from animal model to human studies.Activation of T cells by carbamazepine and carbamazepine metabolites.Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy.Immune mechanism of drug hypersensitivity.Cellular mechanisms of T cell mediated drug hypersensitivity.Direct T-cell stimulations by drugs--bypassing the innate immune system.Pharmacological interaction of drugs with immune receptors: the p-i concept.Cytotoxic T lymphocytes derived from patients with chronic hepatitis C virus infection kill bystander cells via Fas-FasL interactionImportant questions in Allergy: 1--drug allergy/hypersensitivity.Mechanisms of drug-induced allergy.In vitro tests of T cell-mediated drug hypersensitivity.General considerations on rapid desensitization for drug hypersensitivity - a consensus statement.T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays.In vitro diagnosis of T cell-mediated drug allergy.Educational case series: Mechanisms of drug allergy.Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA.International Consensus on drug allergy.T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury.Differences of T-cell activation by the anti-CD3 antibodies Leu4 and BMA030.Etiology and pathogenesis of adverse drug reactions.Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds.[Fever, pneumonia and eosinophilia]Oral prednisolone induced acute generalized exanthematous pustulosis due to corticosteroids of group A confirmed by epicutaneous testing and lymphocyte transformation tests.T cell-mediated reactions to iodinated contrast media: evaluation by skin and lymphocyte activation tests.Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies.A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals.Characterization of drug-specific T cells in lamotrigine hypersensitivity.Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis.Recognition of local anesthetics by alphabeta+ T cells.Involvement of CD80 in the generation of CD4+ cytotoxic T cells.Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide.T cell activation by cross-linking anti-CD3 antibodies with second anti-T cell antibodies: dual antibody cross-linking mimics physical monocyte interaction.Ceftobiprole associated agranulocytosis after drug rash with eosinophilia and systemic symptoms induced by vancomycin and rifampicin
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Werner J. Pichler
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