Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.
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Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion proteinIs tau ready for admission to the prion club?Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseasesProtective effects and mechanisms of sirtuins in the nervous systemSIRT1 and SIRT2: emerging targets in neurodegenerationAmyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer diseaseActivation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expressionPrion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology.Role and Therapeutic Potential of the Pro-Longevity Factor FOXO and Its Regulators in Neurodegenerative Disease.Sirt1: def-eating senescence?Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.Polyphenols: multipotent therapeutic agents in neurodegenerative diseases.SIRT1 in neurodevelopment and brain senescence.Prion degradation pathways: Potential for therapeutic intervention.Treatment of SMB-S15 Cells with Resveratrol Efficiently Removes the PrP(Sc) Accumulation In Vitro and Prion Infectivity In Vivo.Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of Sirt1.Could Sirtuin Activities Modify ALS Onset and Progression?Common themes in PrP signaling: the Src remains the same.The Role of TLR4 and Fyn Interaction on Lipopolysaccharide-Stimulated PAI-1 Expression in Astrocytes.
P2860
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P2860
Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
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name
Neuron dysfunction is induced ...... ion in Caenorhabditis elegans.
@en
Neuron dysfunction is induced ...... ion in Caenorhabditis elegans.
@nl
type
label
Neuron dysfunction is induced ...... ion in Caenorhabditis elegans.
@en
Neuron dysfunction is induced ...... ion in Caenorhabditis elegans.
@nl
prefLabel
Neuron dysfunction is induced ...... ion in Caenorhabditis elegans.
@en
Neuron dysfunction is induced ...... ion in Caenorhabditis elegans.
@nl
P2093
P50
P1476
Neuron dysfunction is induced ...... tion in Caenorhabditis elegans
@en
P2093
Jean-Louis Laplanche
Nicolas Bizat
Patrick Beaudry
Stephane Haïk
Véronique Cochois
P304
P356
10.1523/JNEUROSCI.5831-09.2010
P407
P577
2010-04-01T00:00:00Z