about
Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine.The enzymes of β-lactam biosynthesis.cycloSal-d4TMP pronucleotides structural variations, mechanistic insights and antiviral activity.The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays.Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.A biomimetic domino reaction for the concise synthesis of capreomycidine and epicapreomycidine.Lead structures for new antibacterials: stereocontrolled synthesis of a bioactive muraymycin analogue.The bacterial cell envelope as delimiter of anti-infective bioavailability - An in vitro permeation model of the Gram-negative bacterial inner membrane.NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A-T phosphoramidite building blocks.Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitorMechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY.Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity.Benzyl-functionalized cycloSal-d4T monophosphates.Non-inhibition of acetylcholinesterase by cycloSal nucleotides.Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY.Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction.Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471.Oligonucleotide analogues with cationic backbone linkages.Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and CarbapenamsThioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase SuperfamilyStereoselective Synthesis of Uridine-Derived Nucleosyl Amino AcidsAnalogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core StructuresEnhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological MediaAminoribosylated Analogues of Muraymycin Nucleoside AntibioticsNovel cyclosal nucleotides with reduced inhibitory potency toward human butyrylcholinesteraseNovel 5'-deoxy nucleosyl amino acid scaffolds for the synthesis of muraymycin analoguesConvergence leads to success: total synthesis of the complex nonribosomal peptide polytheonamide BSynthesis and properties of DNA oligonucleotides with a zwitterionic backbone structureEnzymatically Cleavable siRNA Prodrugs: a New Paradigm for the Intracellular Delivery of RNA-Based TherapeuticsEnzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside AntibioticsSpecific, Sensitive, and Quantitative Detection of HER-2 mRNA Breast Cancer Marker by Fluorescent Light-Up Hybridization ProbesMuraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside UnitPyridoxal-5'-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Christian Ducho
@ast
Christian Ducho
@en
Christian Ducho
@es
Christian Ducho
@nl
Christian Ducho
@sl
type
label
Christian Ducho
@ast
Christian Ducho
@en
Christian Ducho
@es
Christian Ducho
@nl
Christian Ducho
@sl
prefLabel
Christian Ducho
@ast
Christian Ducho
@en
Christian Ducho
@es
Christian Ducho
@nl
Christian Ducho
@sl
P106
P21
P31
P496
0000-0002-0629-9993