Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human.
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The janus facet of nanomaterialsComparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicityPregnane X receptor and drug-induced liver injury.Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patientsDifferential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injuryCritical Factors in the Assessment of Cholestatic Liver Injury In Vitro.Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development.The impact of drug transporters on adverse drug reaction.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.High-content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity.Hepatobiliary transporters in drug-induced cholestasis: a perspective on the current identifying tools.A shift in paradigm towards human biology-based systems for cholestatic-liver diseases.Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.ABC gene-ranking for prediction of drug-induced cholestasis in rats.Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver InjuryDevelopment of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.Functional shift with maintained regenerative potential following portal vein ligation.History of hepatic bile formation: old problems, new approaches.Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.
P2860
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P2860
Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human.
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Contribution of high basolater ...... inducing cholestasis in human.
@en
Contribution of high basolater ...... inducing cholestasis in human.
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label
Contribution of high basolater ...... inducing cholestasis in human.
@en
Contribution of high basolater ...... inducing cholestasis in human.
@nl
prefLabel
Contribution of high basolater ...... inducing cholestasis in human.
@en
Contribution of high basolater ...... inducing cholestasis in human.
@nl
P356
P1476
Contribution of high basolater ...... inducing cholestasis in human.
@en
P2093
László Vereczkey
Zsuzsa Veres
P356
10.1093/TOXSCI/KFQ044
P577
2010-02-10T00:00:00Z