Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
about
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityFbxw7 regulates lipid metabolism and cell fate decisions in the mouse liverMicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7Control of cell growth by the SCF and APC/C ubiquitin ligasesTo wake up cancer stem cells, or to let them sleep, that is the questionAdvances in understanding the leukaemia microenvironmentGenetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesChallenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene ExposureFBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung developmentInvestigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestinesMERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signalingDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complexFbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulationTumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancerChemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions.Akt-signal integration is involved in the differentiation of embryonal carcinoma cellsSCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionMyc roles in hematopoiesis and leukemiaRoles of F-box proteins in cancerF-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous mannerHematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cellsThe two faces of FBW7 in cancer drug resistance.Tumor suppressor functions of FBW7 in cancer development and progression.SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasisRegulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environmentControl of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformationRegulation of hematopoietic stem cell fate by the ubiquitin proteasome systemHuman skin neural crest progenitor cells are susceptible to BRAF(V600E)-induced transformationTBK1 regulates prostate cancer dormancy through mTOR inhibition.
P2860
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P2860
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.
@en
Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.
@nl
type
label
Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.
@en
Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.
@nl
prefLabel
Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.
@en
Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.
@nl
P2093
P2860
P50
P356
P1433
P1476
Fbxw7 acts as a critical fail- ...... cells and development of T-ALL
@en
P2093
Akira Hata
Atsushi Iwama
Eriko Nitta
Hiroki Yoshiwara
Hiroko Iwasaki
Ichiro Onoyama
Kana Miyamoto
Keiichi I Nakayama
Keiko Nakayama
Keisuke Ito
P2860
P304
P356
10.1101/GAD.1621808
P577
2008-03-26T00:00:00Z