Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. - Wikidata - wikimedia - TriplyDB

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

http://www.wikidata.org/entity/Q43167778

about

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7 Control of cell growth by the SCF and APC/C ubiquitin ligases To wake up cancer stem cells, or to let them sleep, that is the question Advances in understanding the leukaemia microenvironment Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions.Akt-signal integration is involved in the differentiation of embryonal carcinoma cells SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction Myc roles in hematopoiesis and leukemia Roles of F-box proteins in cancer F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells The two faces of FBW7 in cancer drug resistance.Tumor suppressor functions of FBW7 in cancer development and progression.SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7 Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system Human skin neural crest progenitor cells are susceptible to BRAF(V600E)-induced transformation TBK1 regulates prostate cancer dormancy through mTOR inhibition.

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P2860

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

http://www.wikidata.org/entity/Q43167778

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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name

Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.

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Fbxw7 acts as a critical fail- ...... ells and development of T-ALL.

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Akira Hata

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Atsushi Iwama

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Eriko Nitta

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Hiroki Yoshiwara

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Hiroko Iwasaki

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Ichiro Onoyama

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Keiichi I Nakayama

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Keiko Nakayama

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Keisuke Ito

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P2860

hCDC4 gene mutations in endometrial cancer

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Osteoblastic cells regulate the haematopoietic stem cell niche

Identification of the haematopoietic stem cell niche and control of the niche size

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Ubiquitin ligases: cell-cycle control and cancer

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986-991

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10.1101/GAD.1621808

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