Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. - Wikidata - wikimedia - TriplyDB

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

http://www.wikidata.org/entity/Q43171015

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Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes Axin2 regulates chondrocyte maturation and axial skeletal development Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo.SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis AIMP1 downregulation restores chondrogenic characteristics of dedifferentiated/degenerated chondrocytes by enhancing TGF-β signal.Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.Smad signaling in skeletal development and regeneration.Signaling pathways in cartilage repair.A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.Erg cooperates with TGF-β to control mesenchymal differentiation.Smad7 regulates terminal maturation of chondrocytes in the growth plate Col2CreER(T2), a mouse model for a chondrocyte-specific and inducible gene deletion.Prostaglandin F2α receptor (FP) signaling regulates Bmp signaling and promotes chondrocyte differentiation TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation.Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.Attenuation of the progression of articular cartilage degeneration by inhibition of TGF-β1 signaling in a mouse model of osteoarthritis New findings in osteoarthritis pathogenesis: therapeutic implications.Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.Inhibition of beta-catenin signaling causes defects in postnatal cartilage development.Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.PGE₂ and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways.FGF, TGFβ and Wnt crosstalk: embryonic to in vitro cartilage development from mesenchymal stem cells.TGFβ signaling in cartilage development and maintenance.Developmental mechanisms in articular cartilage degradation in osteoarthritis Nerve growth factor induced after temporomandibular joint inflammation decelerates chondrocyte differentiation.Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling.Phospho-Smad1 modulation by nedd4 E3 ligase in BMP/TGF-β signaling.Hyaluronan promotes the chondrocyte response to BMP-7.A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression.BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.

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P2860

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

http://www.wikidata.org/entity/Q43171015

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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name

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

@en

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

@nl

type

label

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

@en

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

@nl

prefLabel

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

@en

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

@nl

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Journal of Bone and Mineral Research

P1476

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

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P2093

Di Chen

http://www.w3.org/2001/XMLSchema#string

Edward M Schwarz

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Hicham Drissi

http://www.w3.org/2001/XMLSchema#string

Michael Darowish

http://www.w3.org/2001/XMLSchema#string

Michael J Zuscik

http://www.w3.org/2001/XMLSchema#string

Randy N Rosier

http://www.w3.org/2001/XMLSchema#string

Regis J O'Keefe

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Tian-Fang Li

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P2860

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

Controlling TGF-beta signaling

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6

TGFbeta signaling in growth control, cancer, and heritable disorders

Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells

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