Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
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Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomesCeramide synthases at the centre of sphingolipid metabolism and biologyMammalian ceramide synthasesParvoviruses cause nuclear envelope breakdown by activating key enzymes of mitosisCeramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent MannerAntiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.Re-configuration of sphingolipid metabolism by oncogenic transformation.TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis.Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways.Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolismBcl2L13 is a ceramide synthase inhibitor in glioblastoma.Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.Many ceramides.Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3.Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent MannerIAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.Comprehensive lipidome profiling of isogenic primary and metastatic colon adenocarcinoma cell lines.T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules.Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogeneFolate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progressionSphingolipids in colon cancer.TolC-dependent modulation of host cell death by the Francisella tularensis live vaccine strain.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapySensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium.Ceramide synthases in mammalians, worms, and insects: emerging schemes.Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.Sphingolipids in mitochondria.TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways.Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.Role of neutral ceramidase in colon cancer.Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer.Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
P2860
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P2860
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Ceramide synthase 6 modulates ...... spase-3 in colon cancer cells.
@en
Ceramide synthase 6 modulates ...... spase-3 in colon cancer cells.
@nl
type
label
Ceramide synthase 6 modulates ...... spase-3 in colon cancer cells.
@en
Ceramide synthase 6 modulates ...... spase-3 in colon cancer cells.
@nl
prefLabel
Ceramide synthase 6 modulates ...... spase-3 in colon cancer cells.
@en
Ceramide synthase 6 modulates ...... spase-3 in colon cancer cells.
@nl
P2093
P2860
P356
P1433
P1476
Ceramide synthase 6 modulates ...... aspase-3 in colon cancer cells
@en
P2093
B Ogretmen
C Voelkel-Johnson
S White-Gilbertson
P2860
P2888
P304
P356
10.1038/ONC.2008.468
P407
P577
2009-01-12T00:00:00Z
P5875
P6179
1046070160