about
Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.Arylpiperazine derivatives acting at 5-HT(1A) receptors.Alpha,beta-diamino acids: biological significance and synthetic approaches.The medicinal chemistry of agents targeting monoacylglycerol lipase.Update 1 of: α,β-Diamino acids: biological significance and synthetic approaches.Sulfur Groups Improve the Performance of Triazole- and Triazolium-Based Interaction Units in Anion Binding.Development of Fluorescent Ligands for the Human 5-HT1A Receptor.Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.Development of molecular probes for the human 5-HT(6) receptor.Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.Sulfoxide-directed intramolecular [4 + 2] cycloadditions between 2-sulfinyl butadienes and unactivated alkynes.UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.Nucleophilic epoxidation of alpha'-hydroxy vinyl sulfoxides.Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors.Nucleophilic epoxidation of gamma-hydroxyvinyl sulfoxide derivatives.Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin.Sulfur-directed synthesis of enantiopure hydroxy 2-sulfinyl butadienes.Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake.Asymmetric Claisen rearrangements on chiral vinyl sulfoxides.[2,3]-Sigmatropic rearrangements of 3-sulfinyl dihydropyrans: application to the syntheses of the cores of ent-dysiherbaine and deoxymalayamicin A.Sulfur-directed enantioselective synthesis of functionalized dihydropyrans.Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis.Reductive cleavage of tetrahydrofuryl sulfur-substituted oxiranes: application to the formal synthesis of Kumausyne and Kumausallene.Synthesis of highly substituted enantiopure piperazines and ketopiperazines from vicinal N-sulfinyl diamines.Metal-catalyzed oxidation and epoxidation of alpha-hydroxy vinyl and dienyl sulfoxides.Synthesis and structure-activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT(1A) affinity/selectivity.Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.From Allylic Sulfoxides to Allylic Sulfenates: Fifty Years of a Never-Ending [2,3]-Sigmatropic Rearrangement.Gold(I)-Catalyzed Cycloisomerization-Dimerization Cascade of Benzene-Tethered 1,6-Enynes.Chiral Sulfur Functional Groups as Definers of the Chirality at the Metal in Ir and Rh Half-Sandwich Complexes: A Combined CD/X-ray Study.Sulfoxide-controlled S(N)2' displacements between cyanocuprates and epoxy vinyl sulfoxides.Enantiopure 1,4-diols and 1,4-aminoalcohols via stereoselective acyclic sulfoxide-sulfenate rearrangement.Sulfinyl-mediated stereoselective Overman rearrangements and Diels-Alder cycloadditions.Sulfoxide-directed enantioselective synthesis of functionalized tetrahydropyridines.Remote stereocontrol in the synthesis of acyclic 1,4-diols and 1,4-aminoalcohols from 2-sulfinyl dienes.Highly diastereoselective Diels-Alder reactions with enantiopure sulfinyl-substituted 1-hydroxymethyldienes.
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hulumtuese
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wetenschapper
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հետազոտող
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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Alma Viso
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P106
P1153
7004072293
P21
P31
P496
0000-0003-2622-4777