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The development of an ultra performance liquid chromatography-coupled atmospheric pressure chemical ionization mass spectrometry assay for seven adrenal steroids.16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction.A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids.Relative contribution of P450c17 towards the acute cortisol response: Lessons from sheep and goats.Fourth-Generation Progestins Inhibit 3β-Hydroxysteroid Dehydrogenase Type 2 and Modulate the Biosynthesis of Endogenous Steroids.11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored.CYP17 causes hypocortisolism in the South African Angora goat.11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function.Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms.Characterization of a family 54 alpha-L-arabinofuranosidase from Aureobasidium pullulans.11β-Hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways.Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas.Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones.A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A).11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome.Steroid metabolism in breast cancer: Where are we and what are we missing?A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase.Hypocortisolism in the South African angora goat: the role of 3betaHSD.Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders?Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) isoforms.Cytochrome b(5) forms homomeric complexes in living cells.The influence of the amino acid substitution I98K on the catalytic activity of baboon cytochrome P450 side-chain cleavage (CYP11A1).Two CYP17 genes in the South African Angora goat (Capra hircus) - the identification of three genotypes that differ in copy number and steroidogenic output.Intracrine androgen biosynthesis, metabolism and action revisited.Cytochrome b5 augments 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase activity.Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia.The utility of ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS) for clinically relevant steroid analysis.Evidence for the functional role of residues in the B'-C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling.Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry.The identification of two CYP17 alleles in the South African Angora goatExpression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafishAnalysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancerSteroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and MetabolismDifferential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanismsBidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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Karl-Heinz Storbeck
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P108
P106
P1153
6505914358
P21
P31
P496
0000-0003-1669-6383