Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.
about
The fail-safe system to rescue the stalled ribosomes in Escherichia coliA functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosomeThe effect of eukaryotic release factor depletion on translation termination in human cell linesHemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1The invariant uridine of stop codons contacts the conserved NIKSR loop of human eRF1 in the ribosomeTermination of translation: interplay of mRNA, rRNAs and release factors?NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factorIdentification of a cellular factor that modulates HIV-1 programmed ribosomal frameshiftingDifferent modes of stop codon restriction by the Stylonychia and Paramecium eRF1 translation termination factorsmtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAGViable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiaeCommon and specific amino acid residues in the prokaryotic polypeptide release factors RF1 and RF2: possible functional implicationsRibosome-based quality control of mRNA and nascent peptidesCrystal structures of 70S ribosomes bound to release factors RF1, RF2 and RF3Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review)Termination of protein synthesis in mammalian mitochondriaStructure of the Escherichia coli ribosomal termination complex with release factor 2Eukaryotic class 1 translation termination factor eRF1--the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysisInsights into Translational Termination from the Structure of RF2 Bound to the RibosomeCrystal structure of a translation termination complex formed with release factor RF2Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide releaseRecognition of the amber UAG stop codon by release factor RF1Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complexStructure of the Dom34-Hbs1 complex and implications for no-go decayOmnipotent role of archaeal elongation factor 1 alpha (EF1 ) in translational elongation and termination, and quality control of protein synthesisMechanism of activation of methyltransferases involved in translation by the Trm112 'hub' proteinStructural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombeStructural basis for translation termination by archaeal RF1 and GTP-bound EF1 complexStructural basis of highly conserved ribosome recycling in eukaryotes and archaeaStructural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the RibosomeCrystal Structure of the 70S Ribosome Bound with the Q253P Mutant Form of Release Factor RF2Structure of the mammalian ribosomal pre-termination complex associated with eRF1*eRF3*GDPNPSolution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65Fine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome.Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeastTpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay.The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.Mapping functionally important motifs SPF and GGQ of the decoding release factor RF2 to the Escherichia coli ribosome by hydroxyl radical footprinting. Implications for macromolecular mimicry and structural changes in RF2
P2860
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P2860
Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Mutations in the highly conser ...... gger peptidyl-tRNA hydrolysis.
@en
Mutations in the highly conser ...... gger peptidyl-tRNA hydrolysis.
@nl
type
label
Mutations in the highly conser ...... gger peptidyl-tRNA hydrolysis.
@en
Mutations in the highly conser ...... gger peptidyl-tRNA hydrolysis.
@nl
prefLabel
Mutations in the highly conser ...... gger peptidyl-tRNA hydrolysis.
@en
Mutations in the highly conser ...... gger peptidyl-tRNA hydrolysis.
@nl
P2093
P2860
P1433
P1476
Mutations in the highly conser ...... igger peptidyl-tRNA hydrolysis
@en
P2093
G F Sivolobova
L L Kisselev
L Y Frolova
O I Serpinsky
R Y Tsivkovskii
S I Tatkov
V M Blinov
P2860
P304
P356
10.1017/S135583829999043X
P407
P50
P577
1999-08-01T00:00:00Z