Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. - Wikidata - wikimedia - TriplyDB

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.

http://www.wikidata.org/entity/Q43227890

about

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration Neuroprotection for stroke: current status and future perspectives Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation Mechanisms of lead and manganese neurotoxicity Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain.Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species.Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.{EXPRESS] Endocytosis of GluN2B-containing NMDA receptors mediates NMDA-induced excitotoxicity.Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in spontaneously hypertensive rats.Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection.Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.Coupling of the NMDA receptor to neuroprotective and neurodestructive events.Enhanced nitric oxide production during lead (Pb²⁺) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons.Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia.Comparative impact of voltage-gated calcium channels and NMDA receptors on mitochondria-mediated neuronal injury.TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist Calcium-dependent mitochondrial function and dysfunction in neurons.Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia.Molecular neurobiology of lead (Pb(2+)): effects on synaptic function.Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Influence of GluN2 subunit identity on NMDA receptor function.Emerging neuroprotective drugs for the treatment of acute ischaemic stroke.GluN2A versus GluN2B: twins, but quite different.

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Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.

http://www.wikidata.org/entity/Q43227890

description

2008 nî lūn-bûn

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2008年学术文章

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2008年學術文章

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name

Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

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Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

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type

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Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

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Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

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Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

@en

Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

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JNEUROSCI.1207-08.2008

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Journal of Neuroscience

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Specific targeting of pro-deat ...... liance on the NR2B PDZ ligand.

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Anne Vaslin

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Joan Forder

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Marc-Andre Martel

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Michael Tymianski

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Paul Baxter

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Peter Clarke

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Sofia Papadia

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P2860

Calmodulin activates phosphatidylinositol 3-kinase

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists

NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.

Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death.

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.

Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial.

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10696-10710

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10.1523/JNEUROSCI.1207-08.2008

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42

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Giles E. Hardingham

Francesc X Soriano

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2008-10-01T00:00:00Z

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18923045

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2602846

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