about
Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminalsAChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivityA novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptorsSemienzymatic Cyclization of Disulfide-rich Peptides Using Sortase AChemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitroEfficient enzymatic cyclization of an inhibitory cystine knot-containing peptideThe alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channelsDevelopment of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel.Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally AbsorbedRational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients.Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.Therapeutic potential of conopeptides.Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides.Disulfide-rich macrocyclic peptides as templates in drug design.Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain.Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship.Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels.Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels.Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels.High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage.Fmoc-based synthesis of disulfide-rich cyclic peptides.Targeted Delivery of Cyclotides via Conjugation to a NanobodyMembrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gatingPeptides from Mamba Venom as Pain KillersEffects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVIDN- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channelsLateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domainIdentification of a Novel Class of Nicotinic Receptor AntagonistsPeptides – From Discovery to Therapeuticsω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical PotentialEffects of Chirality at Tyr13 on the Structure−Activity Relationships of ω-Conotoxins fromConus magus†Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christina I. Schroeder
@ast
Christina I. Schroeder
@en
Christina I. Schroeder
@es
Christina I. Schroeder
@nl
Christina I. Schroeder
@sl
type
label
Christina I. Schroeder
@ast
Christina I. Schroeder
@en
Christina I. Schroeder
@es
Christina I. Schroeder
@nl
Christina I. Schroeder
@sl
prefLabel
Christina I. Schroeder
@ast
Christina I. Schroeder
@en
Christina I. Schroeder
@es
Christina I. Schroeder
@nl
Christina I. Schroeder
@sl
P1053
K-2042-2014
P106
P1153
7101888003
P21
P31
P3829
P496
0000-0002-6737-6374