YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species.
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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathwayA Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein ReceptorNovel agents for managing dyslipidaemia.Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells.Familial hypercholesterolemia: current treatment and advances in management.Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro.Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus.In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.New lipid-lowering agents.Lipid-lowering therapies in development.Statins inhibit blastocyst formation by preventing geranylgeranylation.Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agentsEmerging options in the treatment of dyslipidemias: a bright future?Squalene monooxygenase - a target for hypercholesterolemic therapy.How can high-throughput screening deliver drugs to treat atherosclerosis?Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha.Effect of YM-53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters.YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents.Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat HepatocytesExperimental model of escape phenomenon in hamsters and the effectiveness of YM-53601 in the model.Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma.Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway
P2860
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P2860
YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-hans
2000年学术文章
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name
YM-53601, a novel squalene syn ...... els in several animal species.
@en
YM-53601, a novel squalene syn ...... els in several animal species.
@nl
type
label
YM-53601, a novel squalene syn ...... els in several animal species.
@en
YM-53601, a novel squalene syn ...... els in several animal species.
@nl
prefLabel
YM-53601, a novel squalene syn ...... els in several animal species.
@en
YM-53601, a novel squalene syn ...... els in several animal species.
@nl
P2093
P2860
P356
P1476
YM-53601, a novel squalene syn ...... els in several animal species.
@en
P2093
H Moritani
M Yamaguchi
S Naganuma
T Ishihara
P2860
P356
10.1038/SJ.BJP.0703545
P407
P577
2000-09-01T00:00:00Z