Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesRegulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and traffickingDysregulation of glutathione homeostasis in neurodegenerative diseasesFriedreich's Ataxia: A Neuronal Point of View on the Oxidative Stress HypothesisMitochondrial iron-sulfur cluster dysfunction in neurodegenerative diseaseA combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial designS-glutathionylation: from molecular mechanisms to health outcomesOxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.Friedreich's ataxia: the vicious circle hypothesis revisited.Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assemblyCurrent experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials.Stem cells from wildtype and Friedreich's ataxia mice present similar neuroprotective properties in dorsal root ganglia cells.Friedreich ataxia: failure of GABA-ergic and glycinergic synaptic transmission in the dentate nucleus.Reversible and irreversible protein glutathionylation: biological and clinical aspects.Mesenchymal stem cells improve motor functions and decrease neurodegeneration in ataxic mice.Redox processes in neurodegenerative disease involving reactive oxygen speciesIron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.Reduced glutathione: a radioprotector or a modulator of DNA-repair activity?Unanswered questions in Friedreich ataxia.Neurodegeneration in Friedreich's ataxia: from defective frataxin to oxidative stressBasic mechanisms of neurodegeneration: a critical update.Current and emerging treatment options in the management of Friedreich ataxia.Neuroprotection: the emerging concept of restorative neural stem cell biology for the treatment of neurodegenerative diseases.Plasmonics for the study of metal ion-protein interactions.Mitochondrial pathophysiology in Friedreich's ataxia.The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: a review.Cysteine-mediated redox signalling in the mitochondria.Oxidative stress in inherited mitochondrial diseases.Friedreich Ataxia: current status and future prospects.Frataxin silencing inactivates mitochondrial Complex I in NSC34 motoneuronal cells and alters glutathione homeostasisFrataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse modelApoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein.Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich's ataxia.Protein glutathionylation in cellular compartments: A constitutive redox signalA novel deletion–insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype
P2860
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P2860
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
@en
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
@nl
type
label
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
@en
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
@nl
prefLabel
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
@en
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities.
@nl
P2093
P50
P1476
Friedreich's ataxia: oxidative stress and cytoskeletal abnormalities
@en
P2093
Alessandro Simonati
Charles Duyckaerts
Filippo Maria Santorelli
Francesco Scaravilli
Laura Maria Gaeta
Marco Sparaco
Michele Feleppa
P304
P356
10.1016/J.JNS.2009.08.052
P577
2009-09-12T00:00:00Z