Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity.
about
Dangerous liaisons: how the immune system deals with factor VIIILocal oxidative stress expansion through endothelial cells--a key role for gap junction intercellular communicationDomain organization of membrane-bound factor VIII.Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IXReplacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXaDimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes.Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets.Factor VIII lacking the C2 domain retains cofactor activity in vitroFactor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity.Thrombin activity propagates in space during blood coagulation as an excitation wave.Membrane-binding properties of the Factor VIII C2 domain.Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII.High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors.The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail.Mass spectrometry-assisted study reveals that lysine residues 1967 and 1968 have opposite contribution to stability of activated factor VIII.Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice.Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells.Distinct roles of Ser-764 and Lys-773 at the N terminus of von Willebrand factor in complex assembly with coagulation factor VIIIPlatelet binding sites for factor VIII in relation to fibrin and phosphatidylserine.Survey of the 2009 commercial optical biosensor literature.Molecular mechanisms of missense mutations that generate ectopic N-glycosylation sites in coagulation factor VIII.
P2860
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P2860
Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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name
Factor VIII C1 domain residues ...... binding and cofactor activity.
@en
Factor VIII C1 domain residues ...... binding and cofactor activity.
@nl
type
label
Factor VIII C1 domain residues ...... binding and cofactor activity.
@en
Factor VIII C1 domain residues ...... binding and cofactor activity.
@nl
prefLabel
Factor VIII C1 domain residues ...... binding and cofactor activity.
@en
Factor VIII C1 domain residues ...... binding and cofactor activity.
@nl
P2093
P1433
P1476
Factor VIII C1 domain residues ...... binding and cofactor activity.
@en
P2093
Alexander B Meijer
David B Cullinan
Gary E Gilbert
Henriët Meems
Koen Mertens
P304
P356
10.1182/BLOOD-2009-01-197707
P407
P577
2009-08-17T00:00:00Z